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Flexibility of neural stem cells [PDF]
Embryonic cortical neural stem cells are self-renewing progenitors that can differentiate into neurons and glia. We generated neurospheres from the developing cerebral cortex using a mouse genetic model that allows for lineage selection and found that ...
Eumorphia eRemboutsika +7 more
doaj +4 more sources
The adult vertebrate central nervous system (CNS) consists of four major differentiated cell types: neurons, astrocytes, oligodendrocytes and ependymal cells. Historically, there has been a disagreement on how these differentiated cell types are generated in the CNS. Progress remains hindered by the complexity of cell structure in this system, the lack
GALLI R. +3 more
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AbstractNeural stem cells (NSCs) have the ability to self‐renew, and are capable of differentiating into neurones, astrocytes and oligodendrocytes. Such cells have been isolated from the developing brain and more recently from the adult central nervous system. This review aims to provide an overview of the current research in this evolving area.
Nigel L, Kennea, Huseyin, Mehmet
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Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]
Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne +8 more
core +17 more sources
Postnatal and adult neurogenesis takes place in the dentate gyrus of the hippocampus in the vast majority of mammals due to the persistence of a population of neural stem cells (NSCs) that also generate astrocytes and more NSCs.
Ane Rodríguez-Bodero +4 more
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The Neurovascular Unit (NVU), composed of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring the physiological functioning of the central nervous system (CNS), which gets affected and
Evangelia Xingi +8 more
doaj +1 more source
In recent papers on neural stem cells, two areas of progress stand out. First, there has been a substantial growth in the published examples of 'transdifferentiation'. Second, there has been progress, albeit more modest, in studies of repair by neural stem cells following transplantation into animal models of disease.
Price, J, Williams, B P
+8 more sources
Summary: Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain.
Estefanía Estévez-Priego +5 more
doaj +1 more source
Abstract‘Human neural stem cells’ jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human neural stem cells (hNSCs) in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements ...
Yu‐Kai Wang +30 more
openaire +2 more sources
[INLINE:1] Brain lesions can cause neural stem cells to activate, proliferate, differentiate, and migrate to the injured area. However, after traumatic brain injury, brain tissue defects and microenvironment changes greatly affect the survival and growth
Xuan-Yu Fang +8 more
doaj +1 more source

