Results 11 to 20 of about 8,348 (225)

Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O-Glycan Degradation and Pathogenicity in a Potentially Multidrug-Resistant Clostridium tertium Strain. [PDF]

Microbiologyopen
The comparative genomic analysis provides information about how C. tertium HGMC01 strain cause disease through mucin glycan degradation, colonization, multidrug resistance, and modulation of immune responses. Moreover, this analysis data suggest that this strain interacts with host cells by degrading mucin in the gut, potentially through recognition or
Kim S, Kang JY, Lee JS.
europepmc   +2 more sources

Improved C5-Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2-Deoxy-2,3-Didehydro-N-Acetyl Neuraminic Acid. [PDF]

ChemMedChem
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Radwan M, Carvajal EG, Cairo CW.
europepmc   +2 more sources

Label-Free and Microplate-Based Dissection of Glycan-Virus Interactions Using Polymer-Tethered Glyconanoparticles. [PDF]

Small Methods
This work demonstrates the use of polymer‐tethered glycosylated gold nanoparticles for the label‐free evaluation of influenza virus binding in a simple microplate. Sialylated linear and branched glycans are integrated using a modular capture and assembly process. The microplate‐based assays are shown to correlate with biolayer interferometry and can be
Richards SJ, Chessa S, Sayer L, Ivanova I, Ahmadipour S, Baker AN, Walker M, Dedola S, Scott KA, Dibben O, Field RA, Gibson MI.   +11 more
europepmc   +2 more sources

A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens

Biochemistry and Biophysics Reports, 2021
Background: Sialic acids are widely distributed in nature and have biological relevance owing to their varied structural and functional roles. Immobilized neuraminidase can selectively remove terminal N-acetyl neuraminic acid from glycoproteins without ...
Lucía Bidondo, Mercedes Landeira, Florencia Festari, Teresa Freire, Cecilia Giacomini   +4 more
doaj   +1 more source

Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.

PLoS Pathogens, 2023
The complement system is the first line of innate immune defense against microbial infections. To survive in humans and cause infections, bacterial pathogens have developed sophisticated mechanisms to subvert the complement-mediated bactericidal activity.
Nicholas D Clark, Christopher Pham, Kurni Kurniyati, Ching Wooen Sze, Laurynn Coleman, Qin Fu, Sheng Zhang, Michael G Malkowski, Chunhao Li   +8 more
doaj   +1 more source

Cold-Active Shewanella glacialimarina TZS-4T nov. Features a Temperature-Dependent Fatty Acid Profile and Putative Sialic Acid Metabolism

Frontiers in Microbiology, 2021
Species of genus Shewanella are among the most frequently identified psychrotrophic bacteria. Here, we have studied the cellular properties, growth dynamics, and stress conditions of cold-active Shewanella strain #4, which was previously isolated from ...
Muhammad Suleman Qasim, Muhammad Suleman Qasim, Mirka Lampi, Minna-Maria K. Heinonen, Berta Garrido-Zabala, Dennis H. Bamford, Reijo Käkelä, Reijo Käkelä, Elina Roine, Elina Roine, Leif Peter Sarin   +10 more
doaj   +1 more source

Discovery Sulfoglycomics and Identification of the Characteristic Fragment Ions for High-Sensitivity Precise Mapping of Adult Zebrafish Brain–Specific Glycotopes

Frontiers in Molecular Biosciences, 2021
Mass spectrometry–based high-sensitivity mapping of terminal glycotopes relies on diagnostic MS2 and/or MS3 ions that can differentiate linkage and define the location of substituents including sulfates.
Huan-Chuan Tseng, Huan-Chuan Tseng, Cheng-Te Hsiao, Nao Yamakawa, Yann Guérardel, Yann Guérardel, Kay-Hooi Khoo, Kay-Hooi Khoo   +7 more
doaj   +1 more source

Sphingolipid composition of human platelets

Journal of Lipid Research, 1973
Total lipid extracts from washed trypsinized human platelets were fractionated into neutral lipids, glycosphingolipids, and phosphclipids by silicic acid chromatography.
Robert V.P. Tao, Charles C. Sweeley, Graham A. Jamieson   +2 more
doaj   +1 more source

Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non-vegetarian dietary patterns

Scientific Reports, 2023
Sialic acids (Sias) are a class of sugar molecules with a parent nine-carbon neuraminic acid, generally present at the ends of carbohydrate chains, either attached to cellular surfaces or as secreted glycoconjugates.
Gerardo N. Guerrero-Flores, Fabio J. Pacheco, Danilo S. Boskovic, Sandaly O. S. Pacheco, Guangyu Zhang, Gary E. Fraser, Fayth L. Miles   +6 more
doaj   +1 more source

Comparison of sialic acid content in bovine and buffalo milk and meat

Revista Científica, 2023
Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò, Simona Rinaldi, Sebastiana Failla   +2 more
doaj   +1 more source