Results 11 to 20 of about 4,739 (156)
Sugar Amino Acid Linkers for the Design of [<sup>18</sup>F]SiFA-PSMA Radioligands. [PDF]
ChemMedChemSugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Gade NR +5 more
europepmc +2 more sources
Analysis of the Role of N-Linked Glycans on Human CD1d Molecules. [PDF]
Cell Biochem FunctABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Bandyopadhyay S, Pradhan S.
europepmc +2 more sources
Development of a C5-Azidoacetamide-Modified 4-Amino-2,3-Difluorosialic Acid Activity-Based Probe for Labeling of Influenza A Neuraminidases. [PDF]
ChembiochemWe report DFSA5Az/DFSA5bio, C5‐azidoacetamide 4‐amino‐2,3‐difluorosialic acid activity‐based probes that trap influenza A viral (IAV) neuraminidases (NA) via a stabilized covalent Tyr‐sialosyl intermediate with hour‐scale reactivation. A bioorthogonal azide enables CuAAC (or one‐step biotin) tagging for activity‐dependent Western‐blot detection at ...
Chao L +6 more
europepmc +2 more sources
Frontiers in Molecular Biosciences, 2021 Mass spectrometry–based high-sensitivity mapping of terminal glycotopes relies on diagnostic MS2 and/or MS3 ions that can differentiate linkage and define the location of substituents including sulfates.
Huan-Chuan Tseng +7 more
doaj +1 more source
Sphingolipid composition of human platelets
Journal of Lipid Research, 1973 Total lipid extracts from washed trypsinized human platelets were fractionated into neutral lipids, glycosphingolipids, and phosphclipids by silicic acid chromatography.
Robert V.P. Tao +2 more
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Scientific Reports, 2023 Sialic acids (Sias) are a class of sugar molecules with a parent nine-carbon neuraminic acid, generally present at the ends of carbohydrate chains, either attached to cellular surfaces or as secreted glycoconjugates.
Gerardo N. Guerrero-Flores +6 more
doaj +1 more source
Comparison of sialic acid content in bovine and buffalo milk and meat
Revista Científica, 2023 Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò +2 more
doaj +1 more source
BMC Biotechnology, 2009 Background Two sequential enzymes in the production of sialic acids, N-acetyl-D-glucosamine 2-epimerase (GlcNAc 2-epimerase) and N-acetyl-D-neuraminic acid aldolase (Neu5Ac aldolase), were overexpressed as double-tagged gene fusions.
Cheng Chung-Hsien +5 more
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Post-Glycosylation Modification of Sialic Acid and Its Role in Virus Pathogenesis
Vaccines, 2019 Sialic acids are a family of nine carbon keto-aldononulosonic acids presented at the terminal ends of glycans on cellular membranes. α-Linked sialoglycoconjugates often undergo post-glycosylation modifications, among which O-acetylation of N-acetyl ...
Simon S. Park
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2010 Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal
Arne Homann +4 more
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