Results 11 to 20 of about 38,379 (201)
Development of a C5-Azidoacetamide-Modified 4-Amino-2,3-Difluorosialic Acid Activity-Based Probe for Labeling of Influenza A Neuraminidases. [PDF]
ChembiochemWe report DFSA5Az/DFSA5bio, C5‐azidoacetamide 4‐amino‐2,3‐difluorosialic acid activity‐based probes that trap influenza A viral (IAV) neuraminidases (NA) via a stabilized covalent Tyr‐sialosyl intermediate with hour‐scale reactivation. A bioorthogonal azide enables CuAAC (or one‐step biotin) tagging for activity‐dependent Western‐blot detection at ...
Chao L +6 more
europepmc +2 more sources
Pneumococcal Neuraminidase [PDF]
Journal of Bacteriology, 1966 Lee, L. T. (Columbia University, New York, N.Y.),and C. Howe. Pneumoccal neuraminidase. J. Bacteriol.91:1418–1426. 1966.—The elaboration of neuraminidase by pneumococci grown under optimal conditions in liquid medium was studied in relation to the bacterial growth cycle.
L T, Lee, C, Howe
openaire +2 more sources
NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?
mBio, 2018 Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential at several points in the virus life cycle. While neuraminidase is
Florian Krammer +9 more
doaj +1 more source
Microglia activated by microbial neuraminidase contributes to ependymal cell death
Fluids and Barriers of the CNS, 2021 The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona +3 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 1994 Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human ...
J. N. S. S. Couceiro, L. G. Baum
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang +11 more
doaj +1 more source
Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
Molecules, 2016 Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda +2 more
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Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child
Emerging Infectious Diseases, 2011 Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi +10 more
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An Overview of Influenza Viruses and Vaccines
Vaccines, 2021 Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda +2 more
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Viruses, 2023 Influenza B virus (IBV) contributes to substantial influenza-mediated morbidity and mortality, particularly among children. Similar to influenza A viruses (IAV), the hemagglutinin (HA) and neuraminidase (NA) of IBV undergo antigenic drift, necessitating ...
Ahmed M. Khalil +5 more
doaj +1 more source