Results 11 to 20 of about 45,170 (239)

Chemoenzymatically Synthesized O-Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context. [PDF]

Angew Chem Int Ed Engl
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhang Z, Liang R, Hooijschuur KC, de Vries RP, Li Z, Boons GJ.   +5 more
europepmc   +3 more sources

Universal type/subtype-specific antibodies for quantitative analyses of neuraminidase in trivalent influenza vaccines

Scientific Reports, 2018
Both influenza viral hemagglutinin and neuraminidase can induce protective immune responses in humans. Although the viral hemagglutinin antigens have been quantified in influenza vaccines, the amounts of neuraminidase remain undetermined.
Kangwei Xu, Changgui Li, Caroline Gravel, Zheng Jiang, Bozena Jaentschke, Gary Van Domselaar, Xuguang Li, Junzhi Wang   +7 more
doaj   +1 more source

Homology modelling and insilico analysis of neuraminidase protein in H1N1 Influenza A virus

Brazilian Archives of Biology and Technology, 2011
In this work, modelling of Neuraminidase protein of Influenza A virus (A/Himeji/1/2009(H1N1)) neuraminidase (NA) protein was done using Modeller 9V2.
Abhilash Manohar
doaj   +1 more source

Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses

Memorias do Instituto Oswaldo Cruz, 1994
Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human ...
J. N. S. S. Couceiro, L. G. Baum
doaj   +1 more source

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fluids and Barriers of the CNS, 2021
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona, Ana León-Rodríguez, María Dolores López-Ávalos, Jesús M. Grondona   +3 more
doaj   +1 more source

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity

Molecules, 2016
Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda, Su-Yan Wang, Josef Voglmeir   +2 more
doaj   +1 more source

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Molecular Therapy: Methods & Clinical Development, 2022
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen   +11 more
doaj   +1 more source

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child

Emerging Infectious Diseases, 2011
Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi, Samir N. Patel, Alicia Sarabia, Rachel R. Higgins, Alexei Savchenko, Peter J. Stojios, Yan Li, Nathalie Bastien, David C. Alexander, Donald E. Low, Jonathan B. Gubbay   +10 more
doaj   +1 more source

An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser   +2 more
doaj   +1 more source

Screening for Neuraminidase Inhibitory Activity in Traditional Chinese Medicines Used to Treat Influenza

Molecules, 2016
Objective: To screen for influenza virus neuraminidase inhibition and to provide a reference for the clinical treatment of influenza using traditional Chinese medicines (TCM).
Xian-Ying Yang, Ai-lin Liu, Shu-jing Liu, Xiao-wei Xu, Lin-Fang Huang   +4 more
doaj   +1 more source