Results 21 to 30 of about 38,379 (201)

Screening for Neuraminidase Inhibitory Activity in Traditional Chinese Medicines Used to Treat Influenza

Molecules, 2016
Objective: To screen for influenza virus neuraminidase inhibition and to provide a reference for the clinical treatment of influenza using traditional Chinese medicines (TCM).
Xian-Ying Yang, Ai-lin Liu, Shu-jing Liu, Xiao-wei Xu, Lin-Fang Huang   +4 more
doaj   +1 more source

R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Emerging Infectious Diseases, 2013
Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors ...
Katrina Sleeman, Zhu Guo, John Barnes, Michael Shaw, James Stevens, Larisa V. Gubareva   +5 more
doaj   +1 more source

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

Frontiers in Endocrinology, 2022
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of the arterial ...
Dignê Tembely, Aubéri Henry, Laetitia Vanalderwiert, Kevin Toussaint, Amar Bennasroune, Sébastien Blaise, Hervé Sartelet, Stéphane Jaisson, Céline Galés, Laurent Martiny, Laurent Duca, Béatrice Romier-Crouzet, Pascal Maurice   +12 more
doaj   +1 more source

Influenza neuraminidase

Influenza and Other Respiratory Viruses, 2011
Please cite this paper as: Air. (2012) Influenza neuraminidase. Influenza and Other Respiratory Viruses 6(4), 245–256.Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of ...
openaire   +3 more sources

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

Molecular Genetics and Metabolism Reports, 2015
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur, S. Akyildiz Demir, C. Marsching, R. Sandhoff, V. Seyrantepe   +4 more
doaj   +1 more source

Influenza’s Newest Trick

mBio, 2019
Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the
Jeffery K. Taubenberger
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

mBio, 2017
Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer   +9 more
doaj   +1 more source

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

mBio, 2023
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different rates under immune selection pressures, anti ...
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen   +13 more
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source