Neuroactive Steroids: Receptor Interactions and Responses [PDF]
Frontiers in Neurology, 2017 Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs).
Kald Beshir Tuem, Tesfay Mehari Atey
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Analytical Methods for the Determination of Neuroactive Steroids [PDF]
Biomolecules, 2021 Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions.
Michal Kaleta +3 more
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Role of neuroactive steroids in the peripheral nervous system [PDF]
Frontiers in Endocrinology, 2011 Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system.
Roberto Cosimo eMelcangi +6 more
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Neuroactive steroids in the programming of neurodevelopment: implications of maternal obesity [PDF]
Frontiers in EndocrinologyNeuroactive steroids synthesized within the maternal-placental-fetal unit play a crucial role in fetal neurodevelopment by regulating cell proliferation, migration, and myelination, neurogenesis, gliogenesis, and synaptogenesis, ultimately shaping brain ...
Carmen J. Zamora-Sánchez +6 more
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The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback? [PDF]
Biomolecules, 2023 Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age.
Vesna Jevtovic-Todorovic +1 more
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Role of Neuroactive Steroids in Health and Disease [PDF]
BiomoleculesSteroidogenesis occurs not only in endocrine peripheral glands (i [...]
Roberto Cosimo Melcangi
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Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders [PDF]
LifePregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors.
Irina Balan +5 more
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Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels [PDF]
Cells, 2020 Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on low-voltage activated T-type Ca2+ channels (T-channels) and γ-aminobutyric acid A (GABAA) receptors ...
Quy L. Tat +5 more
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Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia [PDF]
Biomolecules, 2021 Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms.
Kristina Holubova +7 more
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Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]
Neurobiology of Stress, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli +3 more
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