Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids [PDF]
Frontiers in Molecular Neuroscience, 2022 Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABAAR positive allosteric modulators (PAM).
Thuy N. Vien +4 more
doaj +2 more sources
Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial [PDF]
Life, 2020 Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system.
Gabriela Angelova +11 more
doaj +2 more sources
Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings [PDF]
Frontiers in Psychiatry, 2019 Background: Neuroactive steroids (NAS) affect neurotransmitter systems and cognition; thus, they play role in etiopathogenesis of psychiatric disorders.Aims: The primary aim was to examine cognition and effects of NAS on cognitive functioning in first ...
Pavel Knytl +18 more
doaj +2 more sources
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone? [PDF]
Schizophr Res Treatment, 2016 Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serumlevels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of ...
Belvederi Murri M +12 more
europepmc +9 more sources
Levels of neuroactive steroids are elevated in those who develop first-onset depression early in pregnancy [PDF]
Frontiers in PsychiatryBackgroundAllopregnanolone (ALLO) plays a key role in the pathogenesis of postpartum depression. However, ALLO levels have been variably associated with depression during pregnancy.
Elizabeth S. Wenzel +12 more
doaj +2 more sources
Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model [PDF]
Frontiers in Molecular Neuroscience, 2019 Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil +6 more
doaj +2 more sources
Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age [PDF]
Journal of Veterinary Internal Medicine, 2019 Background Transient hypothalamic‐pituitary‐adrenal axis dysfunction occurs in critically ill foals with sepsis and neonatal maladjustment syndrome (NMS). Cortisol is the most commonly measured steroid.
Monica Aleman +3 more
doaj +2 more sources
Peripartum depression: Current considerations on classification, biological importance and therapeutic potential of neuroactive steroids [PDF]
Vojnosanitetski Pregled, 2022 nema
Marković Miloš, Milovanović Srđan
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Neuroactive Steroids in Schizophrenia [PDF]
The Canadian Journal of Psychiatry, 2005 Schizophrenia is a psychiatric disorder with a complicated pathophysiology, involving many biochemical abnormalities in the brain. Because neuroactive steroids (NASs) modulate neurotransmitter systems that are implicated in the pathology of schizophrenia, recent research has focused on examining the role that NASs play in the illness.
Yanina, Shulman, Philip G, Tibbo
openaire +2 more sources
Therapeutic Advances in Psychopharmacology, 2022 Postpartum depression is one of the most common morbidities of childbearing, yet it is underdiagnosed and undertreated with negative consequences for mother and offspring.
Yardana Kaufman +2 more
doaj +1 more source