Results 21 to 30 of about 8,012 (216)

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]

, 2016
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector, Ghini, Alberto Antonio, Rey, Mariana   +2 more
core   +1 more source

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]

, 2016
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol, Coronel, Maria Florencia, de Nicola, Alejandro Federico, Gonzalez, Susana Laura, Labombarda, Maria Florencia, Raggio, María Celeste, Sánchez Granel, María Luz   +6 more
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Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels

Frontiers in Neuroscience, 2019
BackgroundNeuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders.
Rajendra A. Morey, Rajendra A. Morey, Rajendra A. Morey, Sarah L. Davis, Sarah L. Davis, Courtney C. Haswell, Courtney C. Haswell, Jennifer C. Naylor, Jennifer C. Naylor, Jason D. Kilts, Jason D. Kilts, Steven T. Szabo, Steven T. Szabo, Larry J. Shampine, Larry J. Shampine, Gillian J. Parke, Gillian J. Parke, Delin Sun, Delin Sun, Chelsea A. Swanson, Chelsea A. Swanson, Henry R. Wagner, Henry R. Wagner, Henry R. Wagner, Mid-Atlantic MIRECC Workgroup, Christine E. Marx, Christine E. Marx   +26 more
doaj   +1 more source

Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats

Frontiers in Neuroanatomy, 2022
Sex steroid hormones, such as androgens and estrogens, are known to exert organizational action at perinatal periods and activational effects during adulthood on the brain and peripheral tissues.
Natalia Lagunas, José Manuel Fernández-García, José Manuel Fernández-García, Noemí Blanco, Antonio Ballesta, Antonio Ballesta, Beatriz Carrillo, Beatriz Carrillo, Maria-Angeles Arevalo, Maria-Angeles Arevalo, Paloma Collado, Paloma Collado, Helena Pinos, Helena Pinos, Daniela Grassi, Daniela Grassi, Daniela Grassi, Daniela Grassi   +17 more
doaj   +1 more source

Finasteride Side Effects and Post-Finasteride Syndrome in Male Androgenic Alopecia [PDF]

, 2015
Finasteride is in present a relatively frequent prescribed drug for male androgenic alopecia. The adverse effects reported by some patients seem to be notable, consisting of various (physical, mental/ neurological, sexual, etc.) manifestations which are ...
Ioana, Paunica, Maria, Puiu Gabriela, Mihnea, Manea Costin, Mirela, Manea   +3 more
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Stress, ethanol, and neuroactive steroids [PDF]

Pharmacology & Therapeutics, 2007
Neurosteroids play a crucial role in stress, alcohol dependence and withdrawal, and other physiological and pharmacological actions by potentiating or inhibiting neurotransmitter action. This review article focuses on data showing that the interaction among stress, ethanol, and neuroactive steroids may result in plastic molecular and functional changes
Biggio G, CONCAS, ALESSANDRA, FOLLESA, PAOLO, SANNA, ENRICO, SERRA, MARIANGELA   +4 more
openaire   +3 more sources

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features

Biology of Sex Differences, 2018
Background Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex differences in axonal motor proteins ...
Marzia Pesaresi, Silvia Giatti, Roberto Spezzano, Simone Romano, Silvia Diviccaro, Tiziana Borsello, Nico Mitro, Donatella Caruso, Luis Miguel Garcia-Segura, Roberto Cosimo Melcangi   +9 more
doaj   +1 more source

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
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Neuroactive steroids and the new decade [PDF]

Journal of Neuroendocrinology, 2020
The term ‘neurosteroids’ started to be used in the 1980s to indicate a family of steroids synthesised within the brain and regulating, via steroid receptors or other receptors, several brain functions. Later on, the term ‘neuroactive steroids’ was introduced to include those steroids that are not synthesised in the brain or are only partly me ...
Giancarlo Panzica, Roberto C. Melcangi
openaire   +2 more sources