Results 31 to 40 of about 8,012 (216)

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy

Biomolecules, 2023
The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk of developing dementia.
Silvia Diviccaro, Lucia Cioffi, Rocco Piazza, Donatella Caruso, Roberto Cosimo Melcangi, Silvia Giatti   +5 more
doaj   +1 more source

Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis [PDF]

, 2016
Previous studies have reported an involvement of neuroactive steroids as neuroprotective and anti-inflammatory agents in neurological disorders such as multiple sclerosis (MS); an analysis of their profile during a specific clinical phase of MS is ...
Bues, B., CALIGNANO, ANTONIO, Carotenuto, A., Cerillo, I., Mangone, G., OREFICE, GIUSEPPE, OREFICE, NICOLA SALVATORE, Rehm, R., SACCA', FRANCESCO   +8 more
core   +1 more source

Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

Neural Plasticity, 2015
Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a ...
Valentina Licheri, Giuseppe Talani, Ashish A. Gorule, Maria Cristina Mostallino, Giovanni Biggio, Enrico Sanna   +5 more
doaj   +1 more source

Neuroeconomics of suicide. [PDF]

, 2011
Suicidal behavior is a leading cause of injury and death worldwide. Suicide has been associated with psychiatric illnesses such as depression and schizophrenia, as well as economic uncertainty, and social/cultural factors.
Takahashi, Ph.D Taiki
core   +2 more sources

GABAergic neuroactive steroids: a new frontier in bipolar disorders?

Behavioral and Brain Functions, 2012
Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni, Bhat Krishna M, Preti Antonio   +2 more
doaj   +1 more source

Endogenous neurosteroids influence synaptic GABA_A receptors during post-natal development [PDF]

, 2017
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABA A receptors (GABA ARs), undergoes a temporally specific form of synaptic ...
Agis-Balboa, Agis-Balboa, Agmon, Akk, Akk, Atack, Atack, Bahari-Javan, Banke, Baram, Belelli, Belelli, Belelli, Belelli, Ben-Ari, Ben-Ari, Ben-Ari, Ben-Ari, Bicikova, Blaesse, Bosman, Bourg, Brinton, Brown, Brown, Brown, Butt, Callachan, Cannon, Cellot, Chisari, Cossart, Craig, Crestani, Darbra, Dehorter, Deidda, Del Rio, Do Rego, Do Rego, Doischer, Farrant, Forte, Francis, Franklin, Frau, Fritschy, Gee, Girolamo, Gizerian, Glickfeld, Goldstein, Grobin, Grobin, Grobin, Grobin, Gunn, Gunn, Gunn, Harrison, Hausrat, Heim, Herd, Herd, Hoftman, Hosie, Huntsman, Ivy, Jacob, Jacobson, Jevtovic-Todorovic, Jones, Jones, Jüttner, Kanes, Kessler, Kilb, Kirmse, Korosi, Laurie, Lavoie, Le Magueresse, Lee, Lobo, Locci, Luhmann, Luhmann, Majewska, Maris, Marques-Smith, Melcangi, Mesbah-Oskui, Mody, Mòdol, Nakamura, Neuchterlein, Oh, Okada, Olsen, Olsen, Owens, Panzica, Papadopoulos, Papadopoulos, Patchev, Paysan, Peden, Peters, Pinna, Pinna, Porcu, Purdy, Reddy, Reddy, Reddy, Rice, Rovo, Rudy, Saalmann, Sauer, Schmidt, Schüle, Scioli-Salter, Sernagor, Shu, Shu, Stephens, Takahashi, Tamamaki, Teicher, Thomas, Tokuda, Tremblay, Vallée, Vallée, Vicini, Vida, Volkow, Walker, Wang, Xiao-Jing, Ye, Zhu, Zilberter, Zorumski   +144 more
core   +2 more sources

Neuroactive steroids and peripheral neuropathy

Brain Research Reviews, 2008
Peripheral neuropathy, either inherited or acquired, represents a very common disorder for which effective clinical treatments are not available yet. Observations here summarized indicate that neuroactive steroids, such as progesterone, testosterone and their reduced metabolites, might represent a promising therapeutic option.
I. Roglio, S.Giatti, M. Pesaresi, R. Bianchi, G. Cavaletti, G. Lauria, L. M. Garcia Segura, R.C. Melcangi   +7 more
openaire   +4 more sources

Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected

Diagnostics, 2021
Purpose of review: To discuss and summarize recent findings in peripheral neuropathy (PN) related to connective tissue diseases (CTD) including its prevalence, clinical manifestations, pathogenesis, diagnosis and treatment.
Lei Jin, Yu Liu
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Migraine and cluster headache show impaired neurosteroids patterns [PDF]

, 2019
Background: Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Capi, M., Cicione, C., De Marco, C. M., Di Menna, L., Guglielmetti, M., Koverech, A., Lionetto, L., Maestri, M., Martelletti, P., Negro, A., Nicoletti, F., Passariello, F., Sabbatini, E., Simmaco, M.   +13 more
core   +1 more source