Results 41 to 50 of about 8,012 (216)

The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]

, 2019
Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core   +2 more sources

GABA signaling and neuroactive steroids in adrenal medullary chromaffin cells

Frontiers in Cellular Neuroscience, 2016
GABA is produced not only in the brain, but also in endocrine cells by the two isoforms of glutamic acid decarboxylase (GAD), GAD65 and GAD67. In rat adrenal medullary chromaffin cells only GAD67 is expressed, and GABA is stored in large dense core ...
Keita eHarada, Hidetada eMatsuoka, Hiroaki eFujiwara, Yoichi eUeta, Yuchio eYanagawa, Masumi eInoue   +5 more
doaj   +1 more source

Steroid profiling in male wobbler mouse, a model of Amyotrophic Lateral Sclerosis [PDF]

, 2016
The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology and therapeutic treatment.
Aprahamian, Fanny, Cambourg, Annie, de Nicola, Alejandro Federico, Di Giorgio, Noelia Paula, Gonzalez Deniselle, Maria Claudia, Guennoun, Rachida, Liere, Philippe, Meyer, Maria, Pianos, Antoine, Schumacher, Michael   +9 more
core   +1 more source

Evaluation of Agave angustifolia as a Sustainable Alternative to Synthetic Pesticides: Phytochemical Composition and Multi‐Trophic Bioactivity

Flavour and Fragrance Journal, EarlyView.
The pesticidal potential of Agave angustifolia by assessing its anti‐nematic, antimicrobial, and insecticidal activities, alongside phytochemical profiling. ABSTRACT Plant diseases caused by fungi, bacteria, nematodes, and viruses contribute significantly to annual crop losses and economic hardship. Reliance on chemical pesticides, over a thousand used
Rashika Tamta, Shilpi Rawat, Himani Karakoti, Tannu Rani, Pooja Bargali, Ravendra Kumar, Stefania Garzoli, Renu Pandey   +7 more
wiley   +1 more source

Neurosteroid effects on sensitivity to ethanol

Frontiers in Endocrinology, 2012
Harrison and Simmonds (1984) provided the first clear evidence that neuroactive steroids act at specific neurotransmitter receptors, investigating the potentiation of muscimol-induced GABAA responses by alphaxalone (3α-hydroxy 5α -pregnane l l,20-dione ...
Christa M Helms, David eRossi, Kathleen A Grant, Kathleen A Grant   +3 more
doaj   +1 more source

Altered Steroidome in Women with Gestational Diabetes Mellitus: Focus on Neuroactive and Immunomodulatory Steroids from the 24th Week of Pregnancy to Labor

Biomolecules, 2021
Gestational diabetes mellitus (GDM) is a complication in pregnancy, but studies focused on the steroidome in patients with GDM are not available in the public domain.
Leona Ondřejíková, Antonín Pařízek, Patrik Šimják, Daniela Vejražková, Marta Velíková, Kateřina Anderlová, Michala Vosátková, Hana Krejčí, Michal Koucký, Radmila Kancheva, Michaela Dušková, Markéta Vaňková, Josef Bulant, Martin Hill   +13 more
doaj   +1 more source

The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase [PDF]

, 2008
OBJECTIVES: Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum
Hardoy MC, Dell'osso L, SARDU, CLAUDIA, CARTA, MAURO   +3 more
core   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Neuroactive steroids influence peripheral myelination: A promising opportunity for preventing or treating age-dependent dysfunctions of peripheral nerves [PDF]

, 2013
The process of aging deeply influences morphological and functional parameters of peripheral nerves. The observations summarized here indicate that the deterioration of myelin occurring in the peripheral nerves during aging may be explained by the fall ...
Azcoitia, I., Ballabio, M., Cavarretta, I., García-Segura, Luis M., González, L. C., Leonelli, E., Magnaghi, Valerio, Melcangi, R. C., Veiga, Sergio   +8 more
core   +2 more sources

Neuroactive steroids, neurosteroidogenesis and sex

Progress in Neurobiology, 2019
The nervous system is a target and a source of steroids. Neuroactive steroids are steroids that target neurons and glial cells. They include hormonal steroids originated in the peripheral glands, steroids locally synthesized by the neurons and glial cells (neurosteroids) and synthetic steroids, some of them used in clinical practice. Here we review the
Giatti S., Garcia-Segura L. M., Barreto G. E., Melcangi R. C.   +3 more
openaire   +3 more sources