Results 41 to 50 of about 345,011 (339)

Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma

Frontiers in Genetics, 2022
Neuroblastoma is the most common pediatric extracranial solid tumor. The 5-year survival rate for high-risk neuroblastoma is less than 50%, despite multimodal treatment.
Wanrong Li, Xin Li, Yuren Xia, Jian Wang
doaj   +1 more source

Neuroblastoma

The Lancet, 2007
The survival of patients with high‐risk neuroblastoma has improved significantly with the use of intensive multimodality treatment regimens, including chemotherapy, surgery, radiation therapy, myeloablative chemotherapy followed by stem cell rescue, and ...
C. Chung, T. Boterberg, J. Lucas, J. Panoff, D. Valteau-Couanet, B. Hero, R. Bagatell, C. Hill-Kayser   +7 more
semanticscholar   +1 more source

Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression

BMC Cancer, 2009
Background Neuroblastoma is a pediatric tumor of neural crest cells that is clinically characterized by its variable evolution, from spontaneous regression to malignancy.
Gingras Denis, Barrette Stéphane, Ohta Shigeru, Sartelet Hervé, Nyalendo Carine, Béliveau Richard   +5 more
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miR‐100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children

Cancer Reports, 2023
Background Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life‐threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of
Yufeng Han, Jiaming Chang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He, Wen Fu   +7 more
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DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing [PDF]

, 2016
Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome of 102 well-annotated primary NB tumors
Decock, Anneleen, Ongenaert, Maté, Speleman, Franki, Van Criekinge, Wim, Vandesompele, Jo   +4 more
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Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

Nature Communications, 2021
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features ...
S. Hartlieb, L. Sieverling, Michal Nadler-Holly, M. Ziehm, U. Toprak, C. Herrmann, Naveed Ishaque, K. Okonechnikov, Moritz Gartlgruber, Young-Gyu Park, Elisa M Wecht, L. Savelyeva, K. Henrich, Carolina Rosswog, M. Fischer, B. Hero, David T. W. Jones, E. Pfaff, O. Witt, S. Pfister, R. Volckmann, J. Koster, Katharina Kiesel, K. Rippe, S. Taschner-Mandl, P. Ambros, B. Brors, M. Selbach, L. Feuerbach, F. Westermann   +29 more
semanticscholar   +1 more source

Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model

OncoImmunology, 2020
Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is the primary target for the development of ...
Renske J. E. van den Bijgaart, Michiel Kroesen, Ingrid C. Brok, Daphne Reijnen, Melissa Wassink, Louis Boon, Peter M. Hoogerbrugge, Gosse J Adema   +7 more
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HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line [PDF]

, 2014
Copyright @ 2014 Leotta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brundo, MV, Federico, C, Leotta, CG, Saccone, S, Tosi, S   +4 more
core   +1 more source

Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Induction chemotherapy followed by high-dose therapy with autologous stem cell transplant and subsequent antidisialoganglioside antibody immunotherapy is standard of care for patients with high-risk neuroblastoma, but survival rate among these
Julie R. Park, S. Kreissman, W. London, A. Naranjo, S. Cohn, M. Hogarty, Sheena C. Tenney, D. Haas-Kogan, P. Shaw, J. Kraveka, S. Roberts, J. Geiger, J. Doski, S. Voss, J. Maris, S. Grupp, L. Diller   +16 more
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Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma

Science Translational Medicine, 2020
Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity. CARs to drive off neuroblastoma Neuroblastoma is one of the most common types of pediatric cancer, and ...
K. Straathof, B. Flutter, Rebecca Wallace, N. Jain, T. Loka, S. Depani, Gary Wright, Simone Thomas, G. Cheung, Talia Gileadi, S. Stafford, E. Kokalaki, Jack Barton, C. Marriott, D. Rampling, O. Ogunbiyi, A. Akarca, T. Marafioti, S. Inglott, K. Gilmour, M. Al-Hajj, William P. Day, K. McHugh, L. Biassoni, Natalie Sizer, C. Barton, D. Edwards, I. Dragoni, J. Silvester, K. Dyer, S. Traub, Lily Elson, S. Brook, N. Westwood, L. Robson, A. Bedi, Karen Howe, Ailish Barry, C. Duncan, G. Barone, M. Pule, John Anderson   +41 more
semanticscholar   +1 more source