Results 41 to 50 of about 268,028 (214)

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]

, 2020
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja, Di Florio, Alessia, Eaton, Simon, Hart, Stephen L., Irving, Elsa, Maeshima, Ruhina, Mathiyalakan, Mayuran, Orford, Michael, Shah, Shreya, Simons, Claire, Stoker, Andrew W., Tagalakis, Aristides D.   +11 more
core   +4 more sources

Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression

BMC Cancer, 2009
Background Neuroblastoma is a pediatric tumor of neural crest cells that is clinically characterized by its variable evolution, from spontaneous regression to malignancy.
Gingras Denis, Barrette Stéphane, Ohta Shigeru, Sartelet Hervé, Nyalendo Carine, Béliveau Richard   +5 more
doaj   +1 more source

Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma

Science Translational Medicine, 2020
Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity. CARs to drive off neuroblastoma Neuroblastoma is one of the most common types of pediatric cancer, and ...
K. Straathof, B. Flutter, Rebecca Wallace, N. Jain, T. Loka, S. Depani, Gary Wright, Simone Thomas, G. Cheung, Talia Gileadi, S. Stafford, E. Kokalaki, Jack Barton, C. Marriott, D. Rampling, O. Ogunbiyi, A. Akarca, T. Marafioti, S. Inglott, K. Gilmour, M. Al-Hajj, William P. Day, K. McHugh, L. Biassoni, Natalie Sizer, C. Barton, D. Edwards, I. Dragoni, J. Silvester, K. Dyer, S. Traub, Lily Elson, S. Brook, N. Westwood, L. Robson, A. Bedi, Karen Howe, Ailish Barry, C. Duncan, G. Barone, M. Pule, John Anderson   +41 more
semanticscholar   +1 more source

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]

, 2017
Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht, Claeys, Shana, De Preter, Katleen, Denecker, Geertrui, Durinck, Kaat, Kumps, Candy, Speleman, Franki   +6 more
core   +3 more sources

Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model

OncoImmunology, 2020
Neuroblastoma is a childhood malignancy and in the majority of patients, the primary tumor arises in one of the adrenal glands. Neuroblastoma cells highly express the disialoganglioside GD2, which is the primary target for the development of ...
Renske J. E. van den Bijgaart, Michiel Kroesen, Ingrid C. Brok, Daphne Reijnen, Melissa Wassink, Louis Boon, Peter M. Hoogerbrugge, Gosse J Adema   +7 more
doaj   +1 more source

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas [PDF]

, 2009
This article is available open access through the publisher’s website. Copyright @ 2009 The Authors.Background - Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit ...
Alessandro E. Caccamo, Andrei Thomas-Tikhonenko, Arturo Sala, Behrens, Bian, Brenner, Brignole, Brodeur, Caccamo, Caporali, Cervellera, Chi, Chung, Daisy Corvetta, Devauchelle, Dews, Farina, Giorgia Santilli, Goldman, Grund, Hackett, Hadaschik, He, Hellebrekers, Izabela Piotrowska, John, John Anderson, Julien, Klokov, Knoepfler, Leskov, Lonergan, Lourda, McLaughlin, Meister, Michael D. Hogarty, Michael Dews, Miyake, Miyake, Nakamura, Naugler, Neil J. Sebire, Nizard, Norris, Nourredine Himoudi, Nuutinen, Olesya Chayka, O’Donnell, O’Sullivan, Radisky, Redondo, Rhodes, Sambrook, Santilli, Saverio Bettuzzi, Scaltriti, Schmitz, Schulte, Shannan, Sian Gibson, Steinberg, Takase, Thomas-Tikhonenko, Trougakos, Urban, Ushmorov, Wanzel, Weiss, Winer, Wittke, Wolff, Xie, Zellweger, Zhang, Zhou   +74 more
core   +2 more sources

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments [PDF]

, 2013
Background: Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories.
Beckers, Anneleen, De Brouwer, Sara, Kumps, Candy, Leonelli, Carina, Mestdagh, Pieter, Mets, Evelien, Pattyn, Filip, Rihani, Ali, Rondou, Pieter, Speleman, Franki, Van der Meulen, Joni, Van Maerken, Tom, Van Peer, Gert, Vandesompele, Jo   +13 more
core   +13 more sources

Novel Therapies for Relapsed and Refractory Neuroblastoma

Children, 2018
While recent increases in our understanding of the biology of neuroblastoma have allowed for more precise risk stratification and improved outcomes for many patients, children with high-risk neuroblastoma continue to suffer from frequent disease relapse,
Peter E. Zage
doaj   +1 more source

Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Induction chemotherapy followed by high-dose therapy with autologous stem cell transplant and subsequent antidisialoganglioside antibody immunotherapy is standard of care for patients with high-risk neuroblastoma, but survival rate among these
Julie R. Park, S. Kreissman, W. London, A. Naranjo, S. Cohn, M. Hogarty, Sheena C. Tenney, D. Haas-Kogan, P. Shaw, J. Kraveka, S. Roberts, J. Geiger, J. Doski, S. Voss, J. Maris, S. Grupp, L. Diller   +16 more
semanticscholar   +1 more source

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines [PDF]

, 2017
Neuroblastoma cell lines are an important and cost-effective model used to study oncogenic drivers of the disease. While many of these cell lines have been previously characterized with SNP, methylation, and/or mRNA expression microarrays, there has not ...
Adams, Rebecca N., Davidson, Heather L., Dent, Maiah H., Diamond, Maura A., FORTINA, PAOLO, Harenza, Jo Lynne, Hart, Lori S., Maris, John M., Reynolds, C. Patrick, Song, Michael M.   +9 more
core   +2 more sources