Results 261 to 270 of about 464,323 (316)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells. [PDF]

Stem Cell Reports
Kim D, Kondo T, Inoue H.
europepmc   +1 more source

The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention. [PDF]

RSC Adv
Shitaye G, Dragone M, Mekonnen Z, Tewelde AG, Della Valle M, Caputo G, Mosalaeizadehyazd M, D'Abrosca G, Russo L, Fattorusso R, Isernia C, Malgieri G.   +11 more
europepmc   +1 more source

Erratum: The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources. [PDF]

Neurol Genet
Dilliott AA, Costanzo MC, Bandres-Ciga S, Blauwendraat C, Casey B, Hoang Q, Iwaki H, Jang D, Kim JJ, Leonard HL, Levine KS, Makarious M, Nguyen TT, Rouleau GA, Singleton AB, Smadbeck P, Solle J, Vitale D, Nalls M, Flannick J, Burtt NP, Farhan SMK.   +21 more
europepmc   +1 more source

The m⁶A Modification in Neurodegenerative Disease: A Cellular Perspective. [PDF]

Cells
Wang S, Feng Z, Wu H, Wang S, Qin S, Wang X, Zhou F, Zheng K, Huang X, Liu X.   +9 more
europepmc   +1 more source

Editorial: Advances in neurodevelopmental and neurodegenerative disease research: focus on innovative human-relevant brain research. [PDF]

Front Neurosci
Roe KV, Grassi S, Chiola S, Miller RJ.
europepmc   +1 more source