Results 281 to 290 of about 5,310,608 (313)
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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MicroRNAs in Neurodegenerative Diseases
2017MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain.
Sean, Quinlan +4 more
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Ceruloplasmin in neurodegenerative diseases
Biochemical Society Transactions, 2008Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J, Texel +2 more
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Sumoylation in neurodegenerative diseases
Cellular and Molecular Life Sciences, 2012The yeast SUMO (small ubiquitin-like modifier) orthologue SMT3 was initially discovered in a genetic suppressors screen for the centromeric protein Mif2 (Meluh and Koshland in Mol Bio Cell 6:793-807, 1). Later, it turned out that the homologous mammalian proteins SUMO1 to SUMO4 are reversible protein modifiers that can form isopeptide bonds with lysine
Petranka, Krumova, Jochen H, Weishaupt
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Ageing and neurodegenerative diseases
Ageing Research Reviews, 2010Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation.
Chia-Wei, Hung +4 more
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Cannabinoids and Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets, 2009Although significant advances have taken place in recent years on our understanding of the molecular mechanisms of different neurodegenerative diseases, its translation into effective therapeutic treatments has not been as successful as could be expected.
J, Romero, J Martínez, Orgado
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Glaucoma as a Neurodegenerative Disease
Journal of Neuro-Ophthalmology, 2015The primary pathophysiological feature of glaucoma is a progressive optic neuropathy with characteristic morphological changes of the optic disc and risk factors of age and intraocular pressure. Recently, involvement of other areas of the central nervous system (CNS) beyond the optic nerve has been demonstrated.
Helen V, Danesh-Meyer, Leonard A, Levin
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Biomarkers in Neurodegenerative Diseases
2017The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type of biomarkers has continued to grow for central nervous system diseases, from biofluid-based biomarkers (blood or cerebrospinal fluid (CSF)), to nucleic acids, tissue, and imaging.
Andreas, Jeromin, Robert, Bowser
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AMPK in Neurodegenerative Diseases
2016Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common ...
Manon, Domise, Valérie, Vingtdeux
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SYK coordinates neuroprotective microglial responses in neurodegenerative disease
Cell, 2022Daniel Shapiro +2 more
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