Results 281 to 290 of about 464,323 (316)
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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Ceruloplasmin in neurodegenerative diseases
Biochemical Society Transactions, 2008Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J, Texel +2 more
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Sleep in Neurodegenerative Diseases
Sleep Medicine Clinics, 2016Disorders of sleep are an integral part of neurodegenerative diseases and include insomnia, sleep-wake cycle disruption, excessive daytime sleepiness that may be manifested as persistent somnolence or sudden onset of sleep episodes, obstructive and central sleep apnea, rapid eye movement sleep behavior disorder, and restless legs syndrome.
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Metabolomics of Neurodegenerative Diseases
2015Neurodegenerative diseases are progressive, devastating, and terminal, carrying both personal and societal burden. Currently, their diagnosis depends on their clinical presentation. No quantitative biomarkers exist to enable early verdict and commencement of therapy.
Alejandro, Botas +3 more
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Ageing and neurodegenerative diseases
Ageing Research Reviews, 2010Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation.
Chia-Wei, Hung +4 more
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Cannabinoids and Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets, 2009Although significant advances have taken place in recent years on our understanding of the molecular mechanisms of different neurodegenerative diseases, its translation into effective therapeutic treatments has not been as successful as could be expected.
J, Romero, J Martínez, Orgado
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Curcuminoids in Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery, 2012Neurodegeneration is a term used to describe progressive deterioration of structure and/or function of neurons that affects different parts of the central nervous system and leads to eventual death. Neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and ...
Darrick S H L, Kim +2 more
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Ceruloplasmin in neurodegenerative diseases
Brain Research Reviews, 2005For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link
Vassiliev V, Harris ZL, Zatta P.
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Minocycline and neurodegenerative diseases
Behavioural Brain Research, 2009Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively crossing the blood-brain barrier, effective against gram-positive and -negative infections. In addition to its own antimicrobacterial properties, minocycline has been reported to exert neuroprotective effects over various experimental models such as cerebral ...
Hye-Sun, Kim, Yoo-Hun, Suh
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Biomarkers for neurodegenerative diseases
Current Opinion in Neurology, 2005A major goal of current clinical research in neurodegenerative diseases is to improve early detection of disease and presymptomatic detection of neuronal dysfunction. We also need better tools to assess disease progression in this group of disorders.
Susie M D, Henley +2 more
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