Results 141 to 150 of about 3,008 (200)

Full-Length cDNA Cloning of Human Neuroglobin and Tissue Expression of Rat Neuroglobin

Biochemical and Biophysical Research Communications, 2002
Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and human. However, the full-length cDNA sequence and genomic organization of human neuroglobin have not been reported. In this paper, the full-length cDNA sequence of human neuroglobin was cloned following bioinformatic analysis and ...
Chenggang Zhang, Lingjia Qian, Fuchu He   +2 more
exaly   +3 more sources

Localization of neuroglobin protein in the mouse brain

Neuroscience Letters, 2003
Neuroglobin is a recently discovered vertebrate oxygen-binding respiratory protein. In situ hybridization data demonstrated that neuroglobin-mRNA is widely expressed in neuronal cells of the central and peripheral nervous systems as well as in endocrine cells. The present study was conducted to investigate the presence of neuroglobin protein in neurons
Marc Schmidt, Thorsten Burmester, Thomas Hankeln   +2 more
exaly   +3 more sources

Neuroglobin and friends

Journal of Molecular Recognition, 2017
AbstractIn the year 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Neuroglobin overexpression significantly protects both heart and brain from hypoxic/ischemic and oxidative stress‐related insults, whereas decreased Ngb levels lead to an exacerbation of tissue injuries.
Marco Fiocchetti, Manuela Cipolletti, Valentina Brandi, Fabio Polticelli, Paolo Ascenzi   +4 more
openaire   +3 more sources

Neuroglobin expression in neurogenesis

Neuroscience Letters, 2013
Neuroglobin is a hypoxia-inducible, neuroprotective protein related to myoglobin and hemoglobin, but little is known about its neurodevelopmental expression or function. To begin to explore these issues, we measured neuroglobin protein expression during neuronal differentiation of human embryonic stem cells in vitro and in the neurogenic subventricular
Bryan, Haines, Xiaoou, Mao, Lin, Xie, Steve, Spusta, Xianmin, Zeng, Kunlin, Jin, David A, Greenberg   +6 more
openaire   +2 more sources

Hearing Without Neuroglobin

Neuroscience, 2017
Neuroglobin (Ngb) is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of Ngb in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem ...
Manuela, Nowotny, Lenneke, Kiefer, Daniel, Andre, Andrej, Fabrizius, Thomas, Hankeln, Stefan, Reuss   +5 more
openaire   +2 more sources

Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.

Biochemical and Biophysical Research Communications - BBRC, 2023
Pancreatic cancer is an extremely aggressive malignancy with a very disappointing prognosis. Neuroglobin (NGB), a member of the globin family, has been demonstrated to have a significant role in a variety of tumor forms.
Fan Wu, Jin He, Qianxi Deng, Jun Chen, Mingyu Peng, Jiayi Xiao, Yiwei Zeng, L. Yi, Zhuoqing Li, Rui Tian, Zheng Jiang   +10 more
semanticscholar   +1 more source

The expression of neuroglobin in astrocytoma

Brain Tumor Pathology, 2011
Neuroglobin (NGB) is a characterized heme globin that is widely expressed in the vertebrate central and peripheral nervous system as well as retina and endocrine tissues. However, to date, it is not determined whether functional NGB is expressed in cells of glia origin.
Haojie, Qin, Yadong, Guo, Changquan, Zhang, Lin, Zhang, Mingyuan, Li, Peng, Guan   +5 more
openaire   +2 more sources

Neuroglobin protects against cerebral ischemia/reperfusion injury in rats by suppressing mitochondrial dysfunction and endoplasmic reticulum stress‐mediated neuronal apoptosis through synaptotagmin‐1

Environmental Toxicology, 2023
Cerebral ischemia/reperfusion (I/R) injury remains a grievous health threat, and herein effective therapy is urgently needed. This study explored the protection of neuroglobin (Ngb) in rats with cerebral I/R injury. The focal cerebral I/R rat models were
Lihong Zhang, Di Li, Lin Yin, Ce Zhang, Hong Qu, Jian-Ping Xu   +5 more
semanticscholar   +1 more source

Neuroglobin in the Rat Brain: Localization

Neuroendocrinology, 2008
Neuroglobin (Ngb) is a neuronal hemeprotein similar to myoglobin and hemoglobin and shares their capability for oxygen binding. It has thus been proposed that Ngb acts as an oxygen reservoir or combats reactive oxygen species. In the present study, we investigated the Ngb expression pattern in the rat brain using immunohistochemistry, in situ ...
Hundahl, Christian Ansgar, Allen, Gregg C, Nyengaard, Jens Randel, Dewilde, Sylvia, Carter, Bruce Douglas, Kelsen, Jesper, Hay-Schmidt, Anders   +6 more
openaire   +5 more sources