Results 151 to 160 of about 3,008 (200)

Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress.

Transplantation Proceedings, 2023
BACKGROUND This study aims to investigate whether isoquercitrin (Iso) exerts a neuroprotective role effect after cerebral ischemia-reperfusion (CIR) via up-regulating neuroglobin (Ngb) or reducing oxidative stress.
Xiu-Ping Li, Liming Yi, Xing Liu, Xia Chen, Sanchun Chen, Shichang Cai   +5 more
semanticscholar   +1 more source

The molecular mechanism of redox interaction between neuroglobin and cytochrome c.

International Journal of Biological Macromolecules
Redox interaction between heme proteins - neuroglobin (Ngb) and cytochrome c (Cyt c) is considered to contribute to the Ngb-mediated neuroprotection which mechanism is still unclear.
Z. Bochkova, Marina A Semenova, O. M. Smirnova, Georgy V Maksimov, Andrey B Rubin, M. Kirpichnikov, D. Dolgikh, R. Chertkova, N. Brazhe   +8 more
semanticscholar   +1 more source

Exploiting and Engineering Neuroglobin for Catalyzing Carbene N-H Insertions and the Formation of Quinoxalinones.

Inorganic Chemistry, 2023
It is desired to design and construct more efficient enzymes with better performance to catalyze carbene N-H insertions for the synthesis of bioactive molecules. To this end, we exploited and designed a series of human neuroglobin (Ngb) mutants. As shown
Li-Juan Sun, Huamin Wang, Jia-Kun Xu, Shuqin Gao, G. Wen, Ying Lin   +5 more
semanticscholar   +1 more source

Influence of the intramolecular disulfide Cys46-Cys55 bridge on the interaction of human neuroglobin with SDS.

Journal of Inorganic Biochemistry
Human neuroglobin (hNgb) is a globin involved in the protection of neurons and retinal cells which features an intramolecular disulfide bond between Cys46 and Cys55 under oxidative conditions.
Monica Caselli, L. Sebastianelli, Mirco Meglioli, G. Battistuzzi, M. Borsari   +4 more
semanticscholar   +1 more source

Novel neuroglobin boosters as a therapeutic strategy for traumatic brain injury Ngb boosters for TBI therapy.

International Immunopharmacology
Neuroglobin (Ngb) induction offers a promising strategy for mitigating traumatic brain injury (TBI) damage due to its intrinsic antioxidant properties and capacity to alleviate oxidative stress.
Oscar Hidalgo-lanussa, Tabata Barbosa-Rojas, Paulina Valenzuela-Hormazábal, N. Hofman, David Ramírez, George E Barreto   +5 more
semanticscholar   +1 more source

Neuroglobin: Neuroprotection and neurogenesis

Neuroscience Letters, 2013
Globins, such as hemoglobin, serve as oxygen sensors. Neuroglobin is the globin in brain. It is induced by ischemia and is protective in modeled stroke. Here, Haines et al. describe an additional property of neuroglobin, its expression in progenitor cell populations in brain during development.
openaire   +2 more sources

Presence of neuroglobin in cultured astrocytes

Glia, 2005
AbstractNeuroglobin (Ngb), a recently discovered intracellular respiratory globin in neurons, may play a crucial role in oxygen homeostasis in the brain. We report preliminary findings indicating the presence of functional neuroglobin in primary cultures of cerebral cortical astrocytes. Reverse transcription real‐time polymerase chain reaction (RRT–PCR)
Xiao Qian, Chen, Lu Ye, Qin, Chen Gang, Zhang, Li Tao, Yang, Zhen, Gao, Shuang, Liu, Lok Ting, Lau, Yin-Wan Wendy, Fung, David A, Greenberg, Albert Cheung-Hoi, Yu   +9 more
openaire   +2 more sources

Neuroglobin and neuronal cell survival

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The balance between neuronal apoptosis and survival sculpts the developing brain and has an important role in neurodegenerative diseases. Thus, the individuation of signals that could modulate the cell death machinery as well as enhance survival in neurons promises to provide multiple points of therapeutic intervention in neurodegenerative diseases ...
Fiocchetti M., De Marinis E., Ascenzi P., Marino M.   +3 more
openaire   +3 more sources

ISOTOPICALLY LABELED NEUROGLOBIN BIOSYNTHESIS SYSTEM DEVELOPMENT

Proceedings of the International Conference NT+ME`25 (Gurzuf, from June 1 to June 8, 2025)
The article is devoted to the development of a biosynthesis system for isotopically labeled human neuroglobin. E. coli producer strain was obtained, incubation temperatures, nutrient medium com-position, and expression induction conditions were selected.
M. A. Semenova, O. M. Smirnova, V. Britikov, E. Britikova, Y. V. Bershatsky, E. Bocharov, D. A. Dolgikh, R. Chertkova   +7 more
semanticscholar   +1 more source

NO DEPTH TO NEUROGLOBIN

Journal of Experimental Biology, 2008
![Figure][1] Discovered less than a decade ago, and reported in all vertebrate phyla, the function of the oxygen-binding neuronal heme protein neuroglobin has yet to be determined. Suggested roles include oxygen storage or transport, regenerating NAD+ under anaerobic conditions, or acting ...
openaire   +1 more source