Results 171 to 180 of about 3,990 (214)
Hydrogen sulfide: A whiff of trouble for cancer cell survival. [PDF]
Mol CellNam JS, Dixon MS, Chio IIC.
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Neuroscience, 2017
Neuroglobin (Ngb) is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of Ngb in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem ...
Manuela, Nowotny +5 more
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Neuroglobin (Ngb) is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of Ngb in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem ...
Manuela, Nowotny +5 more
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Journal of Molecular Recognition, 2017
AbstractIn the year 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Neuroglobin overexpression significantly protects both heart and brain from hypoxic/ischemic and oxidative stress‐related insults, whereas decreased Ngb levels lead to an exacerbation of tissue injuries.
Marco Fiocchetti +4 more
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AbstractIn the year 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Neuroglobin overexpression significantly protects both heart and brain from hypoxic/ischemic and oxidative stress‐related insults, whereas decreased Ngb levels lead to an exacerbation of tissue injuries.
Marco Fiocchetti +4 more
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Neuroglobin expression in neurogenesis
Neuroscience Letters, 2013Neuroglobin is a hypoxia-inducible, neuroprotective protein related to myoglobin and hemoglobin, but little is known about its neurodevelopmental expression or function. To begin to explore these issues, we measured neuroglobin protein expression during neuronal differentiation of human embryonic stem cells in vitro and in the neurogenic subventricular
Bryan, Haines +6 more
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Neuroglobin, seven years after
Cellular and Molecular Life Sciences, 2007Neuroglobin is expressed in vertebrates brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation suggests a relevant role in the nervous system, with tight structural restraints. Experiments in vivo and in vitro showed increased hypoxic stress damage upon repressing neuroglobin biosynthesis and improved
BRUNORI, Maurizio, VALLONE, Beatrice
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Neuroglobin in the Rat Brain: Localization
Neuroendocrinology, 2008Neuroglobin (Ngb) is a neuronal hemeprotein similar to myoglobin and hemoglobin and shares their capability for oxygen binding. It has thus been proposed that Ngb acts as an oxygen reservoir or combats reactive oxygen species. In the present study, we investigated the Ngb expression pattern in the rat brain using immunohistochemistry, in situ ...
Hundahl, Christian Ansgar +6 more
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Neuroglobin and neuronal cell survival
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013The balance between neuronal apoptosis and survival sculpts the developing brain and has an important role in neurodegenerative diseases. Thus, the individuation of signals that could modulate the cell death machinery as well as enhance survival in neurons promises to provide multiple points of therapeutic intervention in neurodegenerative diseases ...
Fiocchetti M. +3 more
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Neuroglobin alleviates arsenic-induced neuronal damage
Environmental Toxicology and Pharmacology, 2021People who drink water contaminated with arsenic for a long time develop neuritis, cerebellar symptoms, and deficits in memory and intellectual function. Arsenic induces oxidative stress and promotes apoptosis through multiple signalling pathways in nerve cells.
Xiaona Liu +7 more
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The FASEB Journal, 2017
Neuroglobin (Ngb) has an important role in maintaining homeostasis through processes such as the detoxification of nitrogen, the storage/transport of oxygen, and the protection of neurons at risk of unwanted apoptosis. One of the fascinating differences between neuroglobin and all the other globins is that it has a hexa‐coordinated heme group.
Catherine Lynn Bresniker +8 more
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Neuroglobin (Ngb) has an important role in maintaining homeostasis through processes such as the detoxification of nitrogen, the storage/transport of oxygen, and the protection of neurons at risk of unwanted apoptosis. One of the fascinating differences between neuroglobin and all the other globins is that it has a hexa‐coordinated heme group.
Catherine Lynn Bresniker +8 more
openaire +1 more source
Neuroglobin: Neuroprotection and neurogenesis
Neuroscience Letters, 2013Globins, such as hemoglobin, serve as oxygen sensors. Neuroglobin is the globin in brain. It is induced by ischemia and is protective in modeled stroke. Here, Haines et al. describe an additional property of neuroglobin, its expression in progenitor cell populations in brain during development.
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