Results 171 to 180 of about 3,008 (200)

Abstract A073: Engineered Exosomes Carrying Rabies Viral Glycoprotein (RVG) and Neuroglobin (Ngb) Improved Stroke Outcome in Mouse Model of tMCAo.

Stroke
Delivering therapeutic agents to the central nervous system (CNS) is a significant challenge due to the BBB. To overcome this obstacle, researchers have used the rabies virus glycoprotein (RVG) that is found on the rabies virus envelope, which plays a ...
F. Selina, Justin Kelleher, A. Bushra, Pradip K Kamat, A. Bosomtwi, Ferenc Deák, K. Dhandapani, Joseph A. Frank, M. B. Khan, Ali S. Arbab   +9 more
semanticscholar   +1 more source

Possible Neuroprotective Mechanism of Human Neuroglobin

Annals of the New York Academy of Sciences, 2005
Abstract: Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen. Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo. Recent work on human Ngb has shed light on the mechanism of this neuroprotection by human Ngb,
Wakasugi, K, Kitatsuji, C, Morishima, I
openaire   +2 more sources

Serum Neuroglobin in Acute Traumatic Brain Injury in Children: A Multicenter Case-Control Study.

Neurosurgery
BACKGROUND AND OBJECTIVES Traumatic brain injury (TBI) represents a significant cause of morbidity and mortality in children. This study aimed to delineate the temporal profile of serum neuroglobin in children after TBI and to evaluate its utility as a ...
Khaled Saad, Hala S M Abdelmotogaly, Amira H. El-Ashry, Usama El-Shokhaiby, M. M. Bakr, A. Beheiry, W. Elkholy, Kawashty R. Mohamed, Abdelmonem M. Hassan, Amira A Elhoufey, Anas Elgenidi, Zakaria M. Abdel-Sadek, S. E. Aly, Wesam M. Hussein, Abdulelah Alnusayri, Mohammed S Abdou, T. Alruwaili, S. Taha   +17 more
semanticscholar   +1 more source

Neuroglobin Gone Wild

The FASEB Journal, 2017
Neuroglobin (Ngb) has an important role in maintaining homeostasis through processes such as the detoxification of nitrogen, the storage/transport of oxygen, and the protection of neurons at risk of unwanted apoptosis. One of the fascinating differences between neuroglobin and all the other globins is that it has a hexa‐coordinated heme group.
Catherine Lynn Bresniker, Sandra Ann Martinez, Poetry Anderson, Barrett Bartolomei, Tanner Bingham, Phoebe Bogdon, Jaclyn Dulay, Josh Mergens, Ashley Willow Shipley   +8 more
openaire   +1 more source

Altered hypoxic and hypercapnic ventilatory response following neonatal chronic intermittent hypoxia is associated with changes in serum and brainstem neuroglobin levels

Physiology
Neuroglobin is an oxygen binding heme protein abundantly expressed in neurons (Burmeister et al.2000). It is thought to be neuroprotective, and involved in hypoxia mediated intracellular signaling (Fago et al 2006).
C. Mayer, Sean Ochiagha, P. MacFarlane
semanticscholar   +1 more source

Neuroglobin and Cytoglobin expression in the human brain

Brain Structure and Function, 2012
Neuroglobin and cytoglobin are new members of the heme-globin family. Both globins are primarily expressed in neurons of the brain and retina. Neuroglobin and cytoglobin have been suggested as novel therapeutic targets in various neurodegenerative diseases based on their oxygen binding and cell protecting properties.
Hundahl, Christian Ansgar, Kelsen, Jesper, Hay-Schmidt, Anders   +2 more
openaire   +3 more sources

2718-LB: Lower Serum Neuroglobin Levels Are Associated with Distal Symmetric Polyneuropathy in Type 2 Diabetes: A Cross-Sectional Study

Diabetes
Introduction and Objective: Distal symmetric polyneuropathy (DSPN) is one of the most common chronic complications of type 2 diabetes (T2D) and is associated with substantial morbidity.
Ozgur Yilmaz, O. Erinç, Name Cigra Coskun, Mehmet Demir, Mürvet Algemi, Murat Akarsu   +5 more
semanticscholar   +1 more source

Neuroprotection and the role of neuroglobin

The Lancet, 2003
Daniel J, Garry, Pradeep P A, Mammen
openaire   +2 more sources

The significance of neuroglobin in the brain.

Current medicinal chemistry, 2010
Since its discovery in 2000, neuroglobin (Nb) has been demonstrated to have an essential and conserved function in vertebrates with the consequential discovery of a neuroprotective role. Nb is a member of the globin superfamily and is predominantly expressed in neurons of the central and peripheral nervous system.
S, Hua, S T, Antao, A, Corbett, P K, Witting   +3 more
openaire   +1 more source

Development of Mutant Forms of Neuroglobin with Substitutions in the Interaction Surface with Cytochrome c

Russian journal of bioorganic chemistry, 2023
M. A. Semenova, O. M. Smirnova, A. A. Ignatova, E. Parshina, G. Maksimov, M. Kirpichnikov, D. A. Dolgikh, R. Chertkova   +7 more
semanticscholar   +1 more source