Results 181 to 190 of about 3,990 (214)

Neuroglobin Modification by Reactive Quinone Species

Chemical Research in Toxicology, 2013
The physiological functions of neuroglobin (Ngb), the heme protein of the globin family expressed in the nervous tissue, have not yet been clarified. Besides O2 storage and homeostasis, Ngb is thought to play a role in neuroprotection as a scavenger of toxic reactive species generated in vivo under conditions of oxidative stress.
Nicolis, S, Monzani, E, PEZZELLA, ALESSANDRO, Ascenzi, P, Sbardella, D, Casella, L.   +5 more
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Species-specific functional evolution of neuroglobin

Marine Genomics, 2011
Neuroglobin (Ngb) is a recently discovered vertebrate heme protein that is expressed in the brain and can reversibly bind oxygen. Human Ngb is involved in neuroprotection under oxidative stress conditions such as ischemia and reperfusion. We previously demonstrated that, on the one hand, human ferric Ngb binds to the α-subunit of heterotrimeric G ...
Keisuke, Wakasugi, Nozomu, Takahashi, Hiroyuki, Uchida, Seiji, Watanabe   +3 more
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Possible Neuroprotective Mechanism of Human Neuroglobin

Annals of the New York Academy of Sciences, 2005
Abstract: Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen. Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo. Recent work on human Ngb has shed light on the mechanism of this neuroprotection by human Ngb,
Wakasugi, K, Kitatsuji, C, Morishima, I
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Neuroglobin in Aging Carotid Bodies

2009
Neuroglobin (Ngb) is a member of the vertebrate globin family expressed particularly in the brain and in the retina. Ngb is concentrated in the mitochondria-containing areas of neurons, and its distribution is correlated with oxygen consumption rates. Previously we have shown that Ngb is expressed in carotid body (CB) tissues.
VERRATTI, Vittore, DI GIULIO, Camillo, BIANCHI, Giuseppina, CACCHIO, Marisa Adriana, PETRUCCELLI, GIACOMO, ARTESE, Luciano, Lahiri S, Iturriaga R.   +7 more
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Presence of neuroglobin in cultured astrocytes

Glia, 2005
AbstractNeuroglobin (Ngb), a recently discovered intracellular respiratory globin in neurons, may play a crucial role in oxygen homeostasis in the brain. We report preliminary findings indicating the presence of functional neuroglobin in primary cultures of cerebral cortical astrocytes. Reverse transcription real‐time polymerase chain reaction (RRT–PCR)
Xiao Qian, Chen, Lu Ye, Qin, Chen Gang, Zhang, Li Tao, Yang, Zhen, Gao, Shuang, Liu, Lok Ting, Lau, Yin-Wan Wendy, Fung, David A, Greenberg, Albert Cheung-Hoi, Yu   +9 more
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The expression of neuroglobin in astrocytoma

Brain Tumor Pathology, 2011
Neuroglobin (NGB) is a characterized heme globin that is widely expressed in the vertebrate central and peripheral nervous system as well as retina and endocrine tissues. However, to date, it is not determined whether functional NGB is expressed in cells of glia origin.
Haojie, Qin, Yadong, Guo, Changquan, Zhang, Lin, Zhang, Mingyuan, Li, Peng, Guan   +5 more
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Neuroglobin: Enzymatic reduction and oxygen affinity

Biochemical and Biophysical Research Communications, 2008
Neuroglobin (Ngb) is a hexacoordinate globin expressed in the nervous system of vertebrates, involved in neuroprotection. O(2) equilibrium measurements on mouse Ngb yielded significantly different P(50) values, ranging from approximately 2 torr to approximately 10 torr. By a kinetic approach minimizing the effects of protein autoxidation, we measured P(
GIUFFRE', ALESSANDRO, MOSCHETTI, TOMMASO, VALLONE, Beatrice, BRUNORI, Maurizio   +3 more
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Full-Length cDNA Cloning of Human Neuroglobin and Tissue Expression of Rat Neuroglobin

Biochemical and Biophysical Research Communications, 2002
Neuroglobin is a recently discovered respiratory, porphyrin-containing protein that is expressed in the brain of mouse and human. However, the full-length cDNA sequence and genomic organization of human neuroglobin have not been reported. In this paper, the full-length cDNA sequence of human neuroglobin was cloned following bioinformatic analysis and ...
Chenggang, Zhang, Chunli, Wang, Meiyu, Deng, Lin, Li, Hangyan, Wang, Ming, Fan, Wenlin, Xu, Fanwei, Meng, Lingjia, Qian, Fuchu, He   +9 more
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Neuroglobin–prion protein interaction: what's the function?

Journal of Peptide Science, 2011
AbstractNeuroglobin and cellular prion protein (PrPC) are expressed in the nervous system and co‐localized in the retinal ganglion cell layer. Both proteins do not have an unambiguously assigned function, and it was recently reported that PrPC aggregates rapidly in the presence of neuroglobin, whereas it does not aggregate in the presence of myoglobin,
Palladino P, Scaglione GL, Arcovito A, Vitale RM, Amodeo P, Vallone B, Brunori M, Benedetti E, Rossi F   +8 more
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NO DEPTH TO NEUROGLOBIN

Journal of Experimental Biology, 2008
![Figure][1] Discovered less than a decade ago, and reported in all vertebrate phyla, the function of the oxygen-binding neuronal heme protein neuroglobin has yet to be determined. Suggested roles include oxygen storage or transport, regenerating NAD+ under anaerobic conditions, or acting ...
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