Results 61 to 70 of about 2,582 (167)

Nanomedicines and stroke: Advantages in chronic inflammation treatment and neural regeneration

Neural Regeneration Research
Stroke can be categorized as ischemic and hemorrhagic on the basis of its origin. The pathophysiology following a stroke is complex, and is characterized by ongoing inflammation, neuronal injury, and the accumulation of reactive oxygen species in the ...
Chuhan Liu, Yuanyuan Ran, Changbin Hu, Mengjie Wang, Ning Li, Zhi Yang, Zitong Ding, Chenye Qiao, Jianing Xi, Wei Su, Lin Ye, Zongjian Liu   +11 more
doaj   +1 more source

Molecular Alterations in Ferroptosis and the Effects of Resveratrol: A Systematic Review

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
Ferroptosis is a cell death mechanism characterized by iron overload, accumulation of reactive oxygen species, deficits in glutathione metabolism, lipid peroxidation, and mitochondrial impairments. Resveratrol can prevent or reverse these alterations by chelating iron and upregulating antioxidant defenses. ABSTRACT Ferroptosis is an iron‐dependent cell
Ana Beatriz Dos Santos, Júlio Santos‐Terra, Jaqueline Vieira Carletti, Iohanna Deckmann, Carmem Gottfried   +4 more
wiley   +1 more source

Propofol combined with bone marrow mesenchymal stem cell transplantation improves electrophysiological function in the hindlimb of rats with spinal cord injury better than monotherapy

Neural Regeneration Research, 2015
The repair effects of bone marrow mesenchymal stem cell transplantation on nervous system damage are not satisfactory. Propofol has been shown to protect against spinal cord injury. Therefore, this study sought to explore the therapeutic effects of their
Yue-xin Wang, Jing-jing Sun, Mei Zhang, Xiao-hua Hou, Jun Hong, Ya-jing Zhou, Zhi-yong Zhang   +6 more
doaj   +1 more source

Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease

Neuroprotection, Volume 3, Issue 2, Page 145-164, June 2025.
Common metabolic, histochemical, and molecular pathologies: Type 2 diabetes and dementia. Abstract The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia‐related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysmetabolism.
Stanley S. Schwartz, Elizabeth M. Rhea, William A. Banks, Mary E. Herman   +3 more
wiley   +1 more source

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Frontiers in Immunology, 2018
Many neurologic diseases are related to autoimmune dysfunction and a variety of molecules or reaction pathways are involved in the regulation of immune function of the nervous system. Soluble CD83 (sCD83) is the soluble form of CD83, a specific marker of
Li Bo, Tan Guojun, Guo Li
doaj   +1 more source

Brain fog in Parkinson’s disease: unraveling mechanisms and measuring impact

Frontiers in Neurology
Inconsistent colloquial and professional uses of the term “brain fog” have undermined the potential for empirical study of this symptom complex, and there is no consensus about how to diagnose or treat it. Yet brain fog is frequently reported by patients
Timothy R. Elliott, Xavier Valencia, Susy Chen, Andre Matta   +3 more
doaj   +1 more source

Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting

Neural Regeneration Research, 2015
Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis.
Jun-peng Liu, Yin-zhou Wang, Yong-kun Li, Qiong Cheng, Zheng Zheng   +4 more
doaj   +1 more source

Interferon-α2b Modulates AMPA and Kainate Receptors and Alters Cross Talk of AMPA and NMDA Receptors in the Frog Vestibular Epithelium

Frontiers in Bioscience-Landmark
Background: Interferons (IFNs) are ototoxic drugs leading to vestibular and auditory disorders. This study investigated the effect of pro-inflammatory cytokine IFN-α2b on the afferent glutamatergic synaptic transmission of the ...
Irina V. Ryzhova, Elena A. Vershinina, Alexander G. Markov, Tatyana V. Tobias   +3 more
doaj   +1 more source

Opioid use disorder: current trends and potential treatments

Frontiers in Public Health
Opioid use disorder (OUD) is a major public health threat, contributing to morbidity and mortality from addiction, overdose, and related medical conditions. Despite our increasing knowledge about the pathophysiology and existing medical treatments of OUD,
Yu Kyung Lee, Mark S. Gold, Kenneth Blum, Panayotis K. Thanos, Colin Hanna, Brian S. Fuehrlein   +5 more
doaj   +1 more source

Integrative Machine Learning Framework for Epigenetic Biomarker Discovery and Disease Severity Prediction in Childhood Atopic Dermatitis

Big Data and Cognitive Computing
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is significantly contributed to by epigenetics. We developed a machine learning-based framework to identify DNA methylation biomarkers associated with AD classification and severity ...
Ding-Wei Chen, Yun-Nan Chang
doaj   +1 more source