Results 51 to 60 of about 2,582 (167)

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Daji Guo, Mengjiao Cai, Yanmin Xian, Yinyin Chen, Yujun Feng, Chun Hu, Lizhang Zeng, Lei Shi, Shiqing Zhang   +8 more
wiley   +1 more source

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Frontiers in Immunology
ImportanceResearch is beginning to elucidate the sophisticated mechanisms underlying the microbiota-gut-brain-immune interface, moving from primarily animal models to human studies. Findings support the dynamic relationships between the gut microbiota as
Alison Warren, Yvonne Nyavor, Nikkia Zarabian, Aidan Mahoney, Aidan Mahoney, Leigh A. Frame   +5 more
doaj   +1 more source

The interaction between pain and mental disorders: An interdisciplinary analysis through bibliometrics

Ibrain, Volume 11, Issue 4, Page 476-491, Winter 2025.
This study elucidates the complex relationship between pain and mental disorders via bibliometric analysis. The left section illustrates neural pathways of pain, while the upper right highlights the link between pain and mental states like anxiety, stress, and sleep disorders, showing their interaction in exacerbating pain perception and persistence ...
Zhimin Tan, Qiyu He, Xian Zhang, Jiarong Feng, Yuxin He, Xiaoqiang Li   +5 more
wiley   +1 more source

Placental Alterations in Autism Spectrum Disorder: An In Silico Approach to circRNA–miRNA–mRNA Networks

International Journal of Developmental Neuroscience, Volume 85, Issue 7, November 2025.
The study identified circRNA–miRNA–mRNA interactions in ASD and placenta, finding 71 ASD‐linked circRNA and 30 highly expressed in the placenta. Five genes (SRSF11, PSMD11, NOTCH1, CREBBP, TBL1X) overlapped, with hsa‐MAN1A2_0008 showing a key regulatory potential, highlighting circRNA as possible mediators between ASD and placental alterations ...
Brayan Braz‐Barbosa, Carmem Gottfried, Júlio Santos‐Terra   +2 more
wiley   +1 more source

Neuroinflammation and Neuromodulation in Neurological Diseases

Behavioral Sciences, 2019
Neuroimmunology is a relatively young science. This discipline has emerged today from the research field as a mature and fully developed innovative research area that integrates not only pure topics of neuroimmunology, but also expands on wider fields ...
Maria de los Angeles Robinson-Agramonte, Carlos-Alberto Gonçalves, Roberto Farina de Almeida, Alina González Quevedo, Sandra Chow, Luis Velázquez Pérez, Amado Díaz de la Fé, Patricia Sesterheim, Diogo Onofre Gomes Souza   +8 more
doaj   +1 more source

Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study

Genes, Brain and Behavior, Volume 24, Issue 5, October 2025.
No genome‐wide association study (GWAS) on cognitive function in individuals of Japanese ancestry has been conducted. This study performed GWASs on cognitive function in elderly Japanese individuals, identifying two significant loci on chromosomes 6 and 20 (near PRL, HDGFL1, and BANF2, SNX5).
Genki Shinoda, Taku Obara, Ippei Takahashi, Hisashi Ohseto, Chikana Kawaguchi, Akira Narita, Aoi Noda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Makiko Taira, Hiroshi Sakamoto, Naoki Nakaya, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Shunji Mugikura, Kyoko Suzuki, Shinichi Kuriyama   +18 more
wiley   +1 more source

Neuroprotective effect of interleukin-6 regulation of voltage-gated Na+ channels of cortical neurons is time- and dose-dependent

Neural Regeneration Research, 2015
Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated
Wei Xia, Guo-yi Peng, Jiang-tao Sheng, Fang-fang Zhu, Jing-fang Guo, Wei-qiang Chen   +5 more
doaj   +1 more source

Brain‐Derived Neurotrophic Factor (BDNF) and Sex Differences in Metabolic Regulation

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Brain‐derived neurotrophic factor (BDNF) is expressed in the hypothalamus of both female and male mice (left‐hand side of the panel); however, it exerts distinct functions in either sex, explaining some sexually dimorphic phenotypes in mice and humans (right‐hand side of the panel).
Ariane M. Zanesco, Licio A. Velloso
wiley   +1 more source

The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6

Diagnostics, 2020
Background: activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) plays a key role in schizophrenia (SCZ) and treatment resistant SCZ.
Shatha Rouf Moustafa, Khalid F. Al-Rawi, Drozdstoi Stoyanov, Arafat Hussein Al-Dujaili, Thitiporn Supasitthumrong, Hussein Kadhem Al-Hakeim, Michael Maes   +6 more
doaj   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, Volume 182, Issue 16, Page 3695-3709, August 2025.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source