Results 91 to 100 of about 6,060 (200)

Enterovirus A71 crosses a human blood–brain barrier model through infected immune cells

Microbiology Spectrum
Enterovirus A71 (EV-A71) is associated with neurological conditions such as acute meningitis and encephalitis. The virus is detected in the bloodstream, and high blood viral loads are associated with central nervous system (CNS) manifestations.
Léa Gaume, Hélène Chabrolles, Maxime Bisseux, Igor Lopez-Coqueiro, Lucie Dehouck, Audrey Mirand, Cécile Henquell, Fabien Gosselet, Christine Archimbaud, Jean-Luc Bailly   +9 more
doaj   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Neuroinvasion by Mycoplasma pneumoniae in Acute Disseminated Encephalomyelitis

, 2008
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M.
Gillian L. Genrich, Bernhard Stamm, Michael Moschopulos, Jeannette Guarner, Hansjoerg Hungerbuehler, Sherif R. Zaki, Guarner J, Zaki SR, Stamm B, Moschopulos M, Hungerbuehler H, Genrich GL   +11 more
core   +1 more source

A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model

mBio
Animal models have been instrumental in elucidating the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and in testing coronavirus disease 2019 (COVID-19) vaccines and therapeutics.
Anna Pons-Grífols, Ferran Tarrés-Freixas, Mònica Pérez, Eva Riveira-Muñoz, Dàlia Raïch-Regué, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Barbara Tondelli, Edwards Pradenas, Nuria Izquierdo-Useros, Sara Capdevila, Júlia Vergara-Alert, Victor Urrea, Jorge Carrillo, Ester Ballana, Stephen Forrow, Bonaventura Clotet, Joaquim Segalés, Benjamin Trinité, Julià Blanco   +19 more
doaj   +1 more source

NeuroCOVID: Insights into Neuroinvasion and Pathophysiology

, 2022
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19).
Markus Glatzel, Susanne Krasemann, Hermann C. Altmeppen, Jakob Matschke, Mohsin Shafiq   +4 more
core   +1 more source

Neuroimmune connections in ovine pharyngeal tonsil: potential site for prion neuroinvasion [PDF]

, 2012
peer reviewedRecent studies have proved the possible implication of nasal associated lymphoid tissues, mainly the pharyngeal tonsil, in prion pathogenesis. However, the mechanisms of this neuroinvasion are still being debated.
Berthon, Patricia, Lantier, Frederic, Antoine, Nadine, Lantier, Isabelle, Kirschvink, Nathalie, Daube, Georges, Lantier, Frédéric, F., Piret, Joëlle, Massart, Laurent, Toppets, Vinciane, Grobet, Luc   +10 more
core   +1 more source

Dramatic Reduction of PrPC Level and Glycosylation in Peripheral Nerves following PrP Knock-Out from Schwann Cells Does Not Prevent Transmissible Spongiform Encephalopathy Neuroinvasion [PDF]

, 2009
Expression of the prion protein (PrPC) is a requirement for host susceptibility to the transmissible spongiform encephalopathies (TSEs) and thought to be necessary for the replication and transport of the infectious agent.
Feltri M, Tuzi, Nadia L., Tuzi Nadia L., McCorquodale Caroline, Cancellotti Enrico, Bradford, Barry M.; id_orcid, Manson, Jean C., Cancellotti, Enrico, Feltri, M. Laura, Manson Jean C., McCorquodale, Caroline, Bradford Barry M.   +11 more
core   +1 more source

Neuroinvasion in Prion Diseases: The Roles of Ascending Neural Infection and Blood Dissemination

, 2010
Prion disorders are infectious, neurodegenerative diseases that affect humans and animals. Susceptibility to some prion diseases such as kuru or the new variant of Creutzfeldt-Jakob disease in humans and scrapie in sheep and goats is influenced by ...
Sílvia Sisó, Lorenzo González, Martin Jeffrey   +2 more
core   +1 more source

Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny

Pathogens
Human cytomegalovirus (HCMV) rarely infects the brain following infection of adult individuals. However, the virus readily infects the brain during congenital HCMV (cHCMV) infection, frequently causing severe neurodevelopmental and neurological sequelae.
Fran Krstanović, Andrea Mihalić, Lucija Šakota, Berislav Lisnić, Stipan Jonjić, Ilija Brizić   +5 more
doaj   +1 more source

Influence of pseudorabies virus proteins on neuroinvasion and neurovirulence in mice [PDF]

, 2006
Neurotropism is a distinctive feature of members of the Alphaherpesvirinae. However, its molecular basis remains enigmatic. In the past, research has been focused mainly on the role of viral envelope proteins in modulating herpesvirus neuroinvasion and ...
Fuchs, Walter, Klupp, Barbara, Mettenleiter, Thomas C., Teifke, Jens Peter, Kopp, Martina   +4 more
core   +1 more source