Results 81 to 90 of about 6,060 (200)

Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier

Frontiers in Cellular and Infection Microbiology
IntroductionThe genus Orthoflavivirus of the Flaviviridae family includes several notable pathogens such as mosquito-borne West-Nile virus (Orthoflavivirus nilense, WNV) and Tick-borne encephalitis virus (Orthoflavivirus encephalitidis, TBEV) that are ...
Felix Schweitzer, Felix Schweitzer, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Alina Friedrichs, Alina Friedrichs, Viktoria Gudi, Thomas Skripuletz, Imke Steffen, Imke Steffen, Martin Palus, Martin Palus, Daniel Růžek, Daniel Růžek, Daniel Růžek, Albert Osterhaus, Albert Osterhaus, Chittappen Kandiyil Prajeeth   +17 more
doaj   +1 more source

Viral Infection‐Induced Epilepsy and the Gut Microbiome Crosstalk

WIREs Mechanisms of Disease, Volume 18, Issue 5, September/October 2026.
Viral infections induce neuroinflammation, disrupt gut microbial communities, and increase seizure susceptibility. Understanding how microbiome–immune interactions shape infection‐induced epileptogenesis may reveal novel therapeutic strategies for preventing or reducing epilepsy following viral CNS infections.
Xi Guo, Niomi R. Kaiser, Susan L. Campbell   +2 more
wiley   +1 more source

Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion [PDF]

, 2001
Transmissible spongiform encephalopathies are commonly propagated by extracerebral inoculation of the infectious agent. Indirect evidence suggests that entry into the central nervous system occurs via the peripheral nervous system.
Albers, K M, Markus Glatzel, Glatzel, M, Frank L. Heppner, Adriano Aguzzi, Kathryn M. Albers, Heppner, F L, Aguzzi, A; https://orcid.org/, Albers KM, Heppner FL, Glatzel M, Aguzzi A   +11 more
core   +1 more source

Distinct ZIKV strain signatures and type I IFN modulation reveal a protective role of brain endothelial interferon signaling in vitro and in vivo

Frontiers in Cellular and Infection Microbiology
IntroductionZika virus (ZIKV) infection has been associated with neurological syndromes, particularly during outbreaks caused by Asian lineage strains.
Luan Rocha Lima, Yasmin Mucunã Mustafá, Paula Luize Camargos Fonseca, Sharton Vinícius Antunes Coelho, Pierina Lorencini Parisi, Camila Lopes Simeoni, Lana Monteiro Meuren, Bruno Braz Bezerra, Nathane Cunha Mebus-Antunes, Flavio Matassoli, Flavio Matassoli, Jose Luiz Proença-Modena, Renato Santana Aguiar, Renato Santana Aguiar, Luciana Barros de Arruda   +14 more
doaj   +1 more source

Emergence of Novel Highly Pathogenic Avian Influenza Virus A(H5N1) Clade 2.3.4.4b in Commercial Poultry, Bangladesh

Influenza and Other Respiratory Viruses, Volume 20, Issue 9, September 2026.
ABSTRACT Background The high‐pathogenicity avian influenza (HPAI) viruses represent a main threat to animal and human health, poultry productivity, and ecosystems. The newly evolved A(H5N1) clade 2.3.4.4b has become a worldwide concern for its expanding multihost ecology, including poultry and a wide range of mammalian species.
Mohammed A. Samad, Md Rezaul Karim, Amelia Coggon, Anowar Hossen, A. S. M. Ashab Uddin, Md Golbar Hossain, Guillaume Fournie, Nicola S. Lewis, Alexander M. P. Byrne   +8 more
wiley   +1 more source

Active Vaccination Strategies for Alzheimer's Disease: An Expanded Review

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Overview of immunotherapeutic strategies targeting Alzheimer's disease (AD) pathology and their clinical implications. (Left) Key neuropathological hallmarks of AD, including extracellular amyloid‐beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau (phospho‐Tau), converge to produce synaptic failure, neuroinflammation and neuronal ...
Antonella Comitato, Antonino Neri, Andrea Cossarizza   +2 more
wiley   +1 more source

Measles Virus Fusion Protein: Structure, Function and Inhibition

Viruses, 2016
Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes measles in humans. The Paramyxoviridae family of negative single-stranded enveloped viruses includes several important human and animal pathogens, with MeV causing ...
Philippe Plattet, Lisa Alves, Michael Herren, Hector C. Aguilar   +3 more
doaj   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, Volume 7, Issue 4, August 2026.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion.

, 2000
Transmissible spongiform encephalopathies are often propagated by extracerebral inoculation. The mechanism of spread from peripheral portals of entry to the central nervous system (neuroinvasion) is complex: while lymphatic organs typically show early ...
Markus Glatzel, Glatzel, M, Adriano Aguzzi, Aguzzi, A; https://orcid.org/, Glatzel M, Aguzzi A   +5 more
core   +1 more source

Salivary gland extract from the deer tick, Ixodes scapularis, facilitates neuroinvasion by Powassan virus in BALB/c mice

, 2021
Powassan virus (POWV) is a neuroinvasive flavivirus transmitted to mammals by the bite of ixodid ticks. In this study, we sought to investigate the impact of tick salivary gland extract (SGE) on POWV neuroinvasion.
Reynolds, Erin S, Santos, Rodrigo I, Rodrigo I. Santos, Thangamani, Saravanan, Meghan E. Hermance, Erin S. Reynolds, Saravanan Thangamani, Hermance, Meghan E   +7 more
core   +1 more source