Results 51 to 60 of about 4,528 (158)

Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion

Neural Regeneration Research, 2017
Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear.
Zhi-yuan Li, Yan-ting Yang, Jue Hong, Dan Zhang, Xiao-fei Huang, Li-jie Wu, Huan-gan Wu, Zheng Shi, Jie Liu, Yi Zhu, Xiao-peng Ma   +10 more
doaj   +1 more source

Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

Cell Reports, 2023
Summary: The mechanism by which arcuate nucleus kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate pulsatile hormone secretion remains unknown.
Su Young Han, Paul G. Morris, Jae-Chang Kim, Santosh Guru, Maria Pardo-Navarro, Shel-Hwa Yeo, H. James McQuillan, Allan E. Herbison   +7 more
doaj   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Neurokinin-1 Receptor Regulation of Fibroblast Phenotype and Function

Receptors
Injury to tissue induces the normal wound healing process to repair damage. This is a normal and critical response developed by the body to maintain short-term organ function, and therefore, survival.
Scott P. Levick
doaj   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source

The Pharmacology of Neurokinin Receptors in Addiction: Prospects for Therapy [PDF]

, 2016
Addiction is a chronic disorder in which consumption of a substance or a habitual behavior becomes compulsive and often recurrent, despite adverse consequences.
Sandweiss, Alexander J., Vanderah, Todd W.   +1 more
core  

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Cell Reports, 2020
Summary: Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs).
Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina   +12 more
doaj   +1 more source

Neurokinin receptors subserving plasma extravasation in guinea pig airways [PDF]

, 1995
In the respiratory system the tachykinins substance P and neurokinin A exhibit a variety of effects on airway function that include bronchoconstriction, vasodilatation, and plasma extravasation.
Chantal Savoie, Ian W. Rodger, Chi-Chung Chan, Donna Young, Christine Tousignant   +4 more
core   +1 more source

Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor

Cell & Bioscience, 2023
Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility,
Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang   +11 more
doaj   +1 more source