Results 51 to 60 of about 18,865 (225)

Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

Cell Reports, 2023
Summary: The mechanism by which arcuate nucleus kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate pulsatile hormone secretion remains unknown.
Su Young Han, Paul G. Morris, Jae-Chang Kim, Santosh Guru, Maria Pardo-Navarro, Shel-Hwa Yeo, H. James McQuillan, Allan E. Herbison   +7 more
doaj   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source

Development of Novel Neurokinin 3 Receptor (NK3R) Selective Agonists with Resistance to Proteolytic Degradation

, 2016
Neurokinin B (NKB) regulates the release of gonadotropin-releasing hormone (GnRH) via activation of the neurokinin-3 receptor (NK3R). We evaluated the biological stability of NK3R selective agonists to develop novel NK3R agonists to regulate reproductive
Hiroaki Ohno (1457971), Hiroaki Okamura (486408), Shinya Oishi (164565), Ai Yamada (1730698), Fuko Matsuda (1730704), Nobutaka Fujii (164590), Takashi Yamamura (20115), Ryosuke Misu (1667896), Koki Yamamoto (1730701), Taro Noguchi (698875), Satoshi Ohkura (1730695)   +10 more
core   +1 more source

Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells [PDF]

, 2015
Background: Neurotransmitters, including substance P (SP) and neurokinin A (NKA), are widely distributed in both the central and peripheral nervous system and their receptors, neurokinin-1 receptor (NK1R) and neurokinin-2 receptor (NK2R), are expressed ...
Ohtake, Junya, Shinya Tanaka, Ohno, Yosuke, Kaneumi, Shun, Kentaro Sumida, Toshiyuki Kita, Tanino, Yoshinori, Masuko, Kazutaka, Tanino, Mishie, Junya Ohtake, Tamiko Takemura, Kita, Toshiyuki, Toshiya Shinohara, Yosuke Ohno, Takuto Kishikawa, Hiroya Kobayashi, Sadahiro Iwabuchi, Shinohara, Toshiya, Yoshinori Tanino, Kobayashi, Hiroya, Hidemitsu Kitamura, Kitamura, Hidemitsu, Shun Kaneumi, Sumida, Kentaro, Terada, Satoshi, Kishikawa, Takuto, Kazutaka Masuko, Satoshi Terada, Takemura, Tamiko, Mishie Tanino, Iwabuchi, Sadahiro, Tanaka, Shinya   +31 more
core   +1 more source

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Neurokinin-1 Receptor Regulation of Fibroblast Phenotype and Function

Receptors
Injury to tissue induces the normal wound healing process to repair damage. This is a normal and critical response developed by the body to maintain short-term organ function, and therefore, survival.
Scott P. Levick
doaj   +1 more source

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source