Results 41 to 50 of about 18,865 (225)

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause

Therapeutic Advances in Reproductive Health, 2023
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years ...
Melissa Conklin, Nanette Santoro
doaj   +1 more source

Expression of substance P, neurokinin 1 receptors(NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice

, 2006
—To complete a series of studies on the expression of substance P and neurokinin receptors in mammalian retinas, we investigated the occurrence of these molecules in developing mouse retinas and in retinas of mice with genetic deletion of the ...
BOSCO, L., GANGITANO, C., E. CATALANI, CASINI, GIOVANNI, M. LUCATTELLI, LUCATTELLI, M., C. GANGITANO, DAL MONTE, M., L. BOSCO, FINESCHI, S., BAGNOLI, P., BAGNOLI, PAOLA, CATALANI, E., DAL MONTE, MASSIMO, Catalani, Elisabetta, Gangitano, Carlo, S. FINESCHI, CASINI, G.   +17 more
core   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Frontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama, Hitomi Tsuchida, Mayuko Nagae, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source

Modern Management of the Menopause: Are We Measuring What Matters?

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Assess uptake of the Core Outcomes in Menopause (COMMA) core outcome sets (COS) and examine whether frontline treatments for vasomotor and genitourinary symptoms have been evaluated against these key outcomes. Design Methodological review. Setting Published literature and international clinical trial registries.
Joscelyn Gan, Michelle Steeper, Tim Hillard, Monica Christmas, Jan Shifren, Nick Panay, Martha Hickey, Sarah Lensen   +7 more
wiley   +1 more source

Neurokinin receptor gene expression in substantia nigra: localization, regulation, and potential physiological significance

, 1995
Neurokinin receptor gene expression within the rat and human substantia nigra was examined in detail. In the rat, the relative abundances of nigral neurokinin receptor mRNAs were neurokinin 3 > neurokinin 1 [Formula: see text] neurokinin 2.
Michael J. Bannon, Christopher J. Whitty
core   +1 more source

Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Elinzanetant, a novel, dual neurokinin‐targeted therapy, has been approved in various geographies for the treatment of moderate‐to‐severe vasomotor symptoms (VMS) associated with menopause. Objective To compare the efficacy of elinzanetant with non‐hormonal pharmaceutical treatments (nHT) in alleviating VMS.
Piotr Wojciechowski, Klaudia Kolonko, Andromachi Giannopoulou, Beata Smela, Elżbieta Olewinska, Kristina Rosa Bolling, Jenifer Sassarini, Lee P. Shulman, Vikram Talaulikar   +8 more
wiley   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion

Neural Regeneration Research, 2017
Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear.
Zhi-yuan Li, Yan-ting Yang, Jue Hong, Dan Zhang, Xiao-fei Huang, Li-jie Wu, Huan-gan Wu, Zheng Shi, Jie Liu, Yi Zhu, Xiao-peng Ma   +10 more
doaj   +1 more source