Results 31 to 40 of about 4,528 (158)
Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients [PDF]
, 2015 Objective Cardiovascular diseases are more common in patients with nondipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The aim of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients.
Erselcan, Kubilay +4 more
core +1 more source
Neurokinin receptor gene expression in substantia nigra: localization, regulation, and potential physiological significance [PDF]
, 1995 Neurokinin receptor gene expression within the rat and human substantia nigra was examined in detail. In the rat, the relative abundances of nigral neurokinin receptor mRNAs were neurokinin 3 > neurokinin 1 [Formula: see text] neurokinin 2.
Michael J. Bannon, Christopher J. Whitty
core +1 more source
Therapeutic Advances in Respiratory Disease, 2009 Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin
Venessa Schelfhout +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2010 The purpose of this study is to identify the membrane transport machinery and cell signaling involved in the neurokinin A–inducible release of adenosine triphosphate (ATP) as an autocrine/paracrine signal from cultured guinea-pig taenia coli (T.
Jing Sun +4 more
doaj +1 more source
Discovery of neurokinin antagonists [PDF]
, 2020 : Neurokinins (substance P, neurokinin A, neurokinin B) play an important role in pain transmission, smooth muscle contraction, bronchoconstriction, activation of the immune system, and neurogenic inflammation.
Taka0 Takaya
core
Folia Medica Indonesiana, 2017 Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain.
Yuyun Wirasasmita +3 more
doaj +1 more source
Molecular Pain, 2021 Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic
Jacob CA Edvinsson +5 more
doaj +1 more source
Neurokinin receptors subserving bronchoconstriction [PDF]
, 1995 Tachykinin receptor subtypes were initially defined using agonist potency ratios for the endogenous ligands substance P (SP), neurokinin (NK) A, and NKB. On this basis it was suggested that there are three tachykinin receptor subtypes.
James L. Ellis
core +1 more source
Fertility & Reproduction, 2022 Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely ...
Irene E. SUCQUART +12 more
doaj +1 more source
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Nature Communications, 2019 Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe +6 more
doaj +1 more source