Results 31 to 40 of about 18,865 (225)

Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain

Molecular Pain, 2021
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic
Jacob CA Edvinsson, Philip V Reducha, Majid Sheykhzade, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson   +5 more
doaj   +1 more source

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Nature Communications, 2019
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun   +6 more
doaj   +1 more source

Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model

Fertility & Reproduction, 2022
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely ...
Irene E. SUCQUART, Ruchi NAGARKAR, Melissa C. EDWARDS, Valentina RODRIGUEZ PARIS, Ali AFLATOUNIAN, Michael J. BERTOLDO, Rebecca E. CAMPBELL, Denovan P. BEGG, David J. HANDELSMAN, Vasantha PADMANABHAN, Richard A. ANDERSON, Robert B. GILCHRIST, Kirsty A. WALTERS   +12 more
doaj   +1 more source

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, L. D. D'Andrea, NASTRI, FLAVIA, F. Rossi, F. Nastri, L. D. DANDREA, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO, Rossi F, Filippelli A, Falciani M, Pavone, D'Agostino, D'Andrea, L D, V, Lombardi A, B Nastri F   +23 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study

Pakistan Armed Forces Medical Journal
Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits. Study Design: Laboratory-based experimental study.
Faiqah Ramzan, Ramsha Zahra, Muhammad Haris Ramzan   +2 more
doaj   +1 more source

Medullary tachykinin precursor 1 neurons promote rhythmic breathing

eLife, 2023
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L Horner, Gaspard Montandon   +4 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection: Role of Tachykinin Receptors

Journal of Pharmacological Sciences, 2004
The aim of this work was to verify whether formalin would induce leukocyte recruitment following intraperitoneal (i.p.) injection in rats. Formalin (1.25 – 2.5%) induced cell recruitment, which was concentration- and time-dependent (0 – 24 h).
Júlia M.M. Santos, Maria Aparecida K.F. Tatsuo, Regina Maria M. Turchetti-Maia, Marcela C.G. Lisboa, Janetti N. de Francischi   +4 more
doaj   +1 more source

The Distribution of Neurokinin-1 and Neurokinin-2 Receptors in Human Central Airways [PDF]

American Journal of Respiratory and Critical Care Medicine, 2000
Abstract The precise locations of neurokinin (NK)-1 and NK-2 receptors in human airways, and their role in airway inflammatory diseases, have not been carefully examined. To determine the distribution of NK-1 and NK-2 receptors in human central airways, and to determine whether their distribution was different in smokers, we examined ...
MAPP C. E., MIOTTO D., BRACCIONI F., SAETTA, MARINA, TURATO, GRAZIELLA, MAESTRELLI, PIERO, KRAUSE J. E., KARPITSKIY V., BOYD N., GEPPETTI P., FABBRI L. M.   +10 more
openaire   +6 more sources