Results 11 to 20 of about 4,528 (158)

Neurokinin-1 receptor activation in globus pallidus [PDF]

Frontiers in Neuroscience, 2009
The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen, Lei Chen, Qiao-Ling Cui, Qiao-Ling Cui, Wing-Ho Yung   +4 more
doaj   +2 more sources

The pharmacology of neurokinin receptors in addiction: prospects for therapy [PDF]

Substance Abuse and Rehabilitation, 2015
Alexander J Sandweiss, Todd W VanderahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USAAbstract: Addiction is a chronic disorder in which consumption of a substance or a habitual behavior becomes compulsive and often
Sandweiss AJ, Vanderah TW
doaj   +1 more source

Mapping of neurokinin-like immunoreactivity in the human brainstem [PDF]

BMC Neuroscience, 2003
Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose, Marcos Pilar, Diaz-Cabiale Zaida, Rivada Eva, Salinas Pablo, Smith Victor, Belda Magdalena, Martin Francisco, Coveñas Rafael, Tramu Gerard, Gonzalez-Baron Salvador   +10 more
doaj   +2 more sources

Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights [PDF]

International Journal of Inflammation, 2010
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia   +3 more
doaj   +3 more sources

Substance p immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. [PDF]

, 2013
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Herczeg, László, László Herczeg, Hrabovszky, E, Bloom, SR, Borsay, Beáta Á., Kálmán Rácz, Hrabovszky, Erik, Borsay, BA, Borsay Beáta Á., Ghatei Mohammad A., Liposits Zsolt, Rácz Kálmán, Ciofi Philippe, Ciofi, Philippe, Beáta Á Borsay, Dhillo, WS, Liposits, Z, Herczeg László, Mohammad A Ghatei, Racz, K, Hrabovszky Erik, Dhillo, Waljit S., Ciofi, P, Philippe Ciofi, Ghatei, MA, Liposits, Zsolt, Erik Hrabovszky, Bloom Stephen R., Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Waljit S Dhillo, Herczeg, L, Dhillo Waljit S., Stephen R Bloom, Zsolt Liposits   +35 more
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Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A   +12 more
core   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
core   +1 more source

Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models [PDF]

, 2007
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the ...
Todd, A.J., Riddell, J.S., Scott, D.T., Hughes, D.I.   +3 more
core   +1 more source