Results 11 to 20 of about 119,703,502 (227)

The pharmacology of neurokinin receptors in addiction: prospects for therapy

Substance Abuse and Rehabilitation, 2015
Alexander J Sandweiss, Todd W VanderahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USAAbstract: Addiction is a chronic disorder in which consumption of a substance or a habitual behavior becomes compulsive and often
Sandweiss AJ, Vanderah TW
doaj   +1 more source

Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights [PDF]

International Journal of Inflammation, 2010
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia   +3 more
doaj   +2 more sources

Mapping of neurokinin-like immunoreactivity in the human brainstem [PDF]

BMC Neuroscience, 2003
Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose, Marcos Pilar, Diaz-Cabiale Zaida, Rivada Eva, Salinas Pablo, Smith Victor, Belda Magdalena, Martin Francisco, Coveñas Rafael, Tramu Gerard, Gonzalez-Baron Salvador   +10 more
doaj   +2 more sources

Neurokinin B and pre-eclampsia: a decade of discovery [PDF]

Reproductive Biology and Endocrinology, 2010
At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain
Page Nigel M
doaj   +2 more sources

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide. [PDF]

J Neuroendocrinol
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
DeFazio RA, Burgess CR, Burger LL, Gibson AG, Moenter SM.   +4 more
europepmc   +2 more sources

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A, Tello, Javier; id_orcid   +13 more
core   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
core   +1 more source

Substance P selectively decreases paired pulse depression in the rat hippocampal slice

BMC Neuroscience, 2005
Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
doaj   +1 more source