Results 11 to 20 of about 92,938,436 (228)

The pharmacology of neurokinin receptors in addiction: prospects for therapy

Substance Abuse and Rehabilitation, 2015
Alexander J Sandweiss, Todd W VanderahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USAAbstract: Addiction is a chronic disorder in which consumption of a substance or a habitual behavior becomes compulsive and often
Sandweiss AJ, Vanderah TW
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Neurokinin B and pre-eclampsia: a decade of discovery [PDF]

Reproductive Biology and Endocrinology, 2010
At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain
Page Nigel M
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Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models [PDF]

, 2007
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the ...
Todd, A.J., Riddell, J.S., Scott, D.T., Hughes, D.I.   +3 more
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Substance p immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. [PDF]

, 2013
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Herczeg, László, László Herczeg, Hrabovszky, E, Bloom, SR, Borsay, Beáta Á., Kálmán Rácz, Hrabovszky, Erik, Borsay, BA, Borsay Beáta Á., Ghatei Mohammad A., Liposits Zsolt, Rácz Kálmán, Ciofi Philippe, Ciofi, Philippe, Beáta Á Borsay, Dhillo, WS, Liposits, Z, Herczeg László, Mohammad A Ghatei, Racz, K, Hrabovszky Erik, Dhillo, Waljit S., Ciofi, P, Philippe Ciofi, Ghatei, MA, Liposits, Zsolt, Erik Hrabovszky, Bloom Stephen R., Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Waljit S Dhillo, Herczeg, L, Dhillo Waljit S., Stephen R Bloom, Zsolt Liposits   +35 more
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Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
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Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A   +12 more
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Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
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Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
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Substance P selectively decreases paired pulse depression in the rat hippocampal slice

BMC Neuroscience, 2005
Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
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The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

Therapeutic Advances in Respiratory Disease, 2009
Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin
Venessa Schelfhout, Veerle Van De Velde, Carlo Maggi, Romain Pauwels, Guy Joos   +4 more
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