Results 31 to 40 of about 119,703,502 (227)
Folia Medica Indonesiana, 2017 Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain.
Yuyun Wirasasmita +3 more
doaj +1 more source
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.
, 1998 We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia +23 more
core +1 more source
Fertility & Reproduction, 2022 Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely ...
Irene E. SUCQUART +12 more
doaj +1 more source
Neuronorm is a potent and water soluble neurokinin A receptor antagonist.
, 1998 We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm.
FILIPPELLI, Amelia +21 more
core +1 more source
Advanced Science, EarlyView.Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li +11 more
wiley +1 more source
In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist
, 1990 We studied the effect of [βAla8]neurokinin A-(4-10), a newly developed selective NK-2 tachykinin receptor agonist, on various parameters in anaesthetized rats (blood pressure, urinary bladder motility, plasma extravasation) and guinea-pigs (salivation ...
MANZINI S +7 more
core +1 more source
Journal of Pharmacological Sciences, 2004 The aim of this work was to verify whether formalin would induce leukocyte recruitment following intraperitoneal (i.p.) injection in rats. Formalin (1.25 – 2.5%) induced cell recruitment, which was concentration- and time-dependent (0 – 24 h).
Júlia M.M. Santos +4 more
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
The Distribution of Neurokinin-1 and Neurokinin-2 Receptors in Human Central Airways [PDF]
American Journal of Respiratory and Critical Care Medicine, 2000 Abstract The precise locations of neurokinin (NK)-1 and NK-2 receptors in human airways, and their role in airway inflammatory diseases, have not been carefully examined. To determine the distribution of NK-1 and NK-2 receptors in human central airways, and to determine whether their distribution was different in smokers, we examined ...
MAPP C. E. +10 more
openaire +6 more sources
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Risk‐reducing salpingo‐oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention for women with hereditary cancer predisposition syndromes. When performed before natural menopause, however, RRSO induces immediate surgical menopause, with vasomotor symptoms, sexual dysfunction, accelerated bone loss, and potential long‐term ...
Agnaldo Lopes da Silva Filho +7 more
wiley +1 more source