Results 31 to 40 of about 92,938,436 (228)

The Distribution of Neurokinin-1 and Neurokinin-2 Receptors in Human Central Airways [PDF]

American Journal of Respiratory and Critical Care Medicine, 2000
Abstract The precise locations of neurokinin (NK)-1 and NK-2 receptors in human airways, and their role in airway inflammatory diseases, have not been carefully examined. To determine the distribution of NK-1 and NK-2 receptors in human central airways, and to determine whether their distribution was different in smokers, we examined ...
MAPP C. E., MIOTTO D., BRACCIONI F., SAETTA, MARINA, TURATO, GRAZIELLA, MAESTRELLI, PIERO, KRAUSE J. E., KARPITSKIY V., BOYD N., GEPPETTI P., FABBRI L. M.   +10 more
openaire   +6 more sources

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, L. D. D'Andrea, NASTRI, FLAVIA, F. Rossi, F. Nastri, L. D. DANDREA, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO   +13 more
core   +1 more source

Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause

Therapeutic Advances in Reproductive Health, 2023
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years ...
Melissa Conklin, Nanette Santoro
doaj   +1 more source

Medullary tachykinin precursor 1 neurons promote rhythmic breathing

eLife, 2023
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L Horner, Gaspard Montandon   +4 more
doaj   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists

, 2020
The substance P/neurokinin-1 receptor system has been implicated in tumor cell proliferation. Neurokinin-1 receptor has been identified in different solid tumors but not frequently in hematopoietic malignant cells.
Muñoz Sáez, Miguel, Molinos-Quintana, A., Trujillo-Hacha, P., Piruat, José I., Pérez-Simón, José A., García-Guerrero, Estefanía, Bejarano-García, José A.   +6 more
core   +1 more source

Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights

International Journal of Inflammation, 2010
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia   +3 more
doaj   +1 more source