Results 21 to 30 of about 92,938,436 (228)

Mapping of neurokinin-like immunoreactivity in the human brainstem

BMC Neuroscience, 2003
Background Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.
Narvaez Jose, Marcos Pilar, Diaz-Cabiale Zaida, Rivada Eva, Salinas Pablo, Smith Victor, Belda Magdalena, Martin Francisco, Coveñas Rafael, Tramu Gerard, Gonzalez-Baron Salvador   +10 more
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Possible causes and treatment strategies for the estrus and ovulation disorders in dairy cows

The Journal of Reproduction and Development, 2022
The reproductive performance of dairy cows has declined, along with an increase in their milk yield. First-service conception rates in lactating dairy cows are often lower than 50%.
Natsumi ENDO
doaj   +1 more source

Multidrug Resistance Protein Transporter and Ins(1,4,5)P3-Sensitive Ca2+-Signaling Involved in Adenosine Triphosphate Export via Gq Protein–Coupled NK2-Receptor Stimulation With Neurokinin A

Journal of Pharmacological Sciences, 2010
The purpose of this study is to identify the membrane transport machinery and cell signaling involved in the neurokinin A–inducible release of adenosine triphosphate (ATP) as an autocrine/paracrine signal from cultured guinea-pig taenia coli (T.
Jing Sun, Sadaharu Usune, Yumei Zhao, Keisuke Migita, Takeshi Katsuragi   +4 more
doaj   +1 more source

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

Molecules, 2020
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
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Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction

Frontiers in Endocrinology, 2021
Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama, Mayuko Nagae, Hitomi Tsuchida, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Nature Communications, 2019
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun   +6 more
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Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain

Molecular Pain, 2021
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic
Jacob CA Edvinsson, Philip V Reducha, Majid Sheykhzade, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson   +5 more
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NEUROGENIC MODULATION BY NEUROKININ-1 RECEPTOR ANTAGONIST, CP-96,345 TO INHIBIT RHEUMATOID ARTHRITIS DEVELOPMENT IN ADJUVANT INDUCED ARTHRITIS RAT MODEL

Folia Medica Indonesiana, 2017
Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain.
Yuyun Wirasasmita, Mahardian Rahmadi, Imam Susilo, Junaidi Khotib   +3 more
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Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model

Fertility & Reproduction, 2022
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely ...
Irene E. SUCQUART, Ruchi NAGARKAR, Melissa C. EDWARDS, Valentina RODRIGUEZ PARIS, Ali AFLATOUNIAN, Michael J. BERTOLDO, Rebecca E. CAMPBELL, Denovan P. BEGG, David J. HANDELSMAN, Vasantha PADMANABHAN, Richard A. ANDERSON, Robert B. GILCHRIST, Kirsty A. WALTERS   +12 more
doaj   +1 more source

Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection: Role of Tachykinin Receptors

Journal of Pharmacological Sciences, 2004
The aim of this work was to verify whether formalin would induce leukocyte recruitment following intraperitoneal (i.p.) injection in rats. Formalin (1.25 – 2.5%) induced cell recruitment, which was concentration- and time-dependent (0 – 24 h).
Júlia M.M. Santos, Maria Aparecida K.F. Tatsuo, Regina Maria M. Turchetti-Maia, Marcela C.G. Lisboa, Janetti N. de Francischi   +4 more
doaj   +1 more source