Results 101 to 110 of about 12,605,538 (213)

Comparative Analysis of Deep Learning‐Based Algorithms for Peptide Structure Prediction

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT While of primary importance in both the biomedical and therapeutic fields, peptides suffer from a relative lack of dedicated tools to predict efficiently and accurately their 3D structures despite being a crucial step in understanding their physio‐pathological function or designing new drugs. In recent years, deep‐learning methods have enabled
Clément Sauvestre, Jean‐François Zagury, Florent Langenfeld   +2 more
wiley   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source

Neuronal circuitry for pain processing in the dorsal horn [PDF]

, 2010
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception.
A Dhaka, A Ribeiro-da-Silva, A Ribeiro-da-Silva, AF Keller, AG Brown, AH Watson, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AL Bailey, AM Taylor, Andrew J. Todd, AR Light, AW Hantman, AW Hantman, B Lynn, B Rexed, BA Graham, C Albuquerque, C Gauriau, C Gauriau, C Gauriau, C Torsney, CJ Woodbury, CJ Woodbury, CJ Woolf, D Andrew, D Lima, D Lima, D Lima, D Lima, D Schoffnegger, D Schoffnegger, D Uta, DI Hughes, DI Hughes, DI Hughes, DJ Cavanaugh, DJ Maxwell, DL Bennett, DS Bredt, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, ET Zhang, ET Zhang, G Kato, GG Nagy, GJ Bennett, GJ Michael, GT Whiteside, H Baba, H Bester, H Ikeda, H Ikeda, H Sakamoto, HJ Hu, HY Huang, I Decosterd, I Laing, J Sandkuhler, J Scholz, J Zheng, JA Coull, JA Esteban, JF Bernard, JH Hwang, JJ Azkue, JL Hylden, JM Castro-Lopes, K Abe, K Feil, K Noguchi, KA Moore, KM Al-Khater, KM Al-Khater, KS Al Ghamdi, L Almarestani, L Sivilotti, LE Lorenzo, M Antal, M Antal, M Gassner, M Larsson, M Malcangio, M Mori, M Naim, M Okamoto, M Randic, M Rethelyi, M Zoli, MB Plenderleith, MJ Eaton, MJ Perry, MJ Zylka, ML Nichols, MM Heinricher, MM Naim, MW Salter, NK Littlewood, P Boscan, P Brumovsky, P Shortland, PD Wall, PW Mantyh, PW Mantyh, Q Liu, R Burstein, R Ruscheweyh, R Ruscheweyh, RC Spike, RC Spike, RM Slugg, RP Seal, RR Ji, S Neumann, S Neumann, SA Prescott, SA Shehab, SF Santos, SH Kim, SN Lawson, SP Schneider, T Ibuki, T Kemp, T Kohno, T Yasaka, T Yasaka, TJ Grudt, TL Yaksh, TP Malan, VS Seybold, WD Snider, WD Willis, X Zhang, X Zhang, XH Yu, Y Lu, Y Lu, Y Lu, YG Tong, YQ Ding, Z Puskár, ZS Han   +159 more
core   +1 more source

New Insights into the Control of Pulsatile GnRH Release: the Role of Kiss1/Neurokinin B Neurons

Frontiers in Endocrinology, 2012
Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release.
Víctor M. Navarro
doaj   +1 more source

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source

Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans [PDF]

, 2010
We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2weighted echo planar imaging.
Ackland, Akopyan, Banzett, Bertrand, Bianchi, Brannan, Cavanna, Cechetto, Chamberlin, Chamberlin, Chen, Colebatch, Corfield, Corfield, Critchley, Dick, Douglas, Douglas, Douglas R. Corfield, Duvernoy, Duvernoy, Evans, Evans, Fink, Fink, Friston, Friston, Gandevia, Gaytan, Gray, Haines, Harper, Herbert, Heywood, Hugo D. Critchley, Isaev, Kevin Murphy, Kjaer, Koos, Kubin, Kumar, Lavezzi, Leanne C. McKay, Macey, McKay, McKay, McKay, Middleton, Mink, Nathan, Pattinson, Peiffer, Plum, Plum, Ramsay, Richard S.J. Frackowiak, Schmahmann, Schwarzacher, Severinghaus, Shea, Skatrud, Smith, Smith, Talairach, Wenninger, Worsley, Xu, Yokota   +67 more
core   +2 more sources

Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway

iScience
Summary: Tachykinins are short neuropeptides, such as substance P and neurokinin B, that have been shown to interact with Alzheimer’s β-amyloid (Aβ) peptide.
Mohsen Habibnia, Eric Catalina-Hernandez, Mario Lopez-Martin, David Masnou-Sanchez, Alex Peralvarez-Marin   +4 more
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus [PDF]

, 2018
The superficial dorsal horn (laminae I and II) of the spinal cord contains numerous excitatory and inhibitory interneurons, and recent studies have shown that each of these groups can be divided into several neurochemically distinct populations. Although
Bell, Andrew M., Gutierrez-Mecinas, Maria, Hérau, Marine, Polgár, Erika, Todd, Andrew J.   +4 more
core   +1 more source

The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats

The Journal of Reproduction and Development, 2019
This study aimed to investigate the efficacy of a newly developed NK3 receptor agonist (B21-750) on the secretion of luteinizing hormone (LH) in association with ovarian steroid hormones during the follicular phase (FP, n = 5) and luteal phase (LP, n = 5)
Larasati Puji RAHAYU, Natsumi ENDO, Shinji KUWAI, Shinya OISHI, Tomomi TANAKA   +4 more
doaj   +1 more source