Results 121 to 130 of about 12,605,538 (213)

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala. [PDF]

, 2020
Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/
Hnasko, TS, Khom, S, Roberto, M, Steinkellner, T   +3 more
core  

Physiological Functions and Molecular Mechanisms of Neurokinin B in Fish

Progress in Fishery Sciences
Neurokinin B (NKB) is a hypothalamic neuropeptide containing 10 amino acids and is an essential member of the tachykinin family. Based on studies in mammals, Kiss, NKB, and dynorphin A are located in the common neurons, named KNDy neurons, and NKB and ...
Bin WANG, Zhenfang TIAN, Huiying GUO, Yongjiang XU, Aijun CUI, Yan JIANG   +5 more
doaj   +1 more source

NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

eLife, 2018
Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus.
Chrysanthi Fergani, Silvia Leon, Stephanie L Padilla, Anne MJ Verstegen, Richard D Palmiter, Victor M Navarro   +5 more
doaj   +1 more source

Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications

Obesity Reviews, EarlyView.
ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Shaohua Zhang, Xinmeng Sun, Haiyun Guan, Rongmin Wang, Wei Zhang, Hexia Xia   +5 more
wiley   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

eLife, 2016
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu, Casey C Nestor, Chunguang Zhang, Stephanie L Padilla, Richard D Palmiter, Martin J Kelly, Oline K Rønnekleiv   +6 more
doaj   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

Suppressive Effects of Glycyrrhetinic Acid Derivatives on Tachykinin Receptor Activation and Hyperalgesia

Journal of Pharmacological Sciences, 2011
.: Glycyrrhetinic acid (GA), an aglycone of glycyrrhizin, isolated from the licorice root (Glycyrrhizia), and its semi-synthetic derivatives have a wide range of pharmacological effects. To investigate whether GA derivatives may be used as a new class of
Yuko Akasaka, Atsushi Sakai, Kumiko Takasu, Michiko Tsukahara, Akira Hatta, Hidenori Suzuki, Hideo Inoue   +6 more
doaj   +1 more source

The neurokinin B pathway in the treatment of menopausal hot flushes

Climacteric, 2019
Hot flushes remain a debilitating aspect of menopause, disrupting daytime activities and sleep, and may last for years. Estrogen replacement is an effective treatment, but takes time to become maximally effective and is contraindicated in a significant ...
R. Anderson, K. Skorupskaite, J. Sassarini   +2 more
semanticscholar   +1 more source