Results 171 to 180 of about 10,500,405 (214)
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Stimulation of Cl Secretion by Neurokinin A and Neurokinin B in Canine Tracheal Epithelium
American Review of Respiratory Disease, 1988Abstract We studied the effects of neurokinin A (NKA) and neurokinin B (NKB), the mammalian-derived tachykinins, on the electrical and ion transport properties of canine tracheal epithelium. Both tachykinins dose-dependently increased short-circuit current (Isc) when added to the mucosal (NKA: = 24.2 ± 2.4 µA/cm2, KD = 9 nM; NKB: = 14.
J, Tamaoki +3 more
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Biofizika, 2005
The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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Distribution of neurokinin A-like and neurokinin B-like immunoreactivity in human peripheral tissues
Regulatory Peptides, 1991Using specific radioimmunoassay and immunocytochemistry for neurokinin A (NKA) and neurokinin B (NKB), distribution and localization of the two peptides in human peripheral tissues were studied. Both NKA-like immunoreactivity (NKA-LI) and NKB-like immunoreactivity (NKB-LI) were present in the walls of the gut and gall bladder and in the pancreas.
S, Kishimoto +7 more
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Clinical Translational Studies of Kisspeptin and Neurokinin B
Seminars in Reproductive Medicine, 2019AbstractKisspeptin and neurokinin B (NKB) are hypothalamic neuropeptides that are vital for reproductive health. An absence of either kisspeptin or NKB signaling results in hypogonadotrophic hypogonadism and a failure to proceed through puberty. In recent years, several studies have demonstrated potential avenues for the clinical utility of medications
Tia, Hunjan, Ali, Abbara
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Brain Research, 1989
The regional distributions of neurokinin B-like immunoreactivity and substance P-like immunoreactivity in the central nervous system in spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKYs) were examined. The distribution of neurokinin B-like immunoreactivity in WKYs was not exactly the same as that of substance P-like ...
A, Nagashima +5 more
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The regional distributions of neurokinin B-like immunoreactivity and substance P-like immunoreactivity in the central nervous system in spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKYs) were examined. The distribution of neurokinin B-like immunoreactivity in WKYs was not exactly the same as that of substance P-like ...
A, Nagashima +5 more
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Visual Neuroscience, 1989
AbstractThe mammalian tachykinin peptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB) are encoded by distinct mRNAs derived from separate preprotachykinin (PPT) genes. The SP/NKA-encoding PPT gene generates three mRNAs by alternative RNA processing: α-PPT mRNA, which encodes SP only, and β- and γ-PPT mRNAs, which encode both SP and ...
N C, Brecha +3 more
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AbstractThe mammalian tachykinin peptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB) are encoded by distinct mRNAs derived from separate preprotachykinin (PPT) genes. The SP/NKA-encoding PPT gene generates three mRNAs by alternative RNA processing: α-PPT mRNA, which encodes SP only, and β- and γ-PPT mRNAs, which encode both SP and ...
N C, Brecha +3 more
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Neurokinin B and Its Receptor in Hypogonadotropic Hypogonadism
2010The hypothalamus integrates multiple environmental and developmental cues relevant to reproductive function, serving to transduce these into a pulsatile output of gonadotropin-releasing hormone (GnRH). Although neuroanatomical and physiological studies have yielded key clues about the functional organisation of the so-called 'GnRH pulse generator ...
Robert K, Semple, A Kemal, Topaloglu
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Biofizika, 2005
The conformational features of some glycine-monosubstituted analogues of neurokinins A and B were investigated by the method of theoretical conformational analysis. The calculated geometry and energy parameters permitted one to determine the structural role of each of these substituted amino acids in the mechanism of folding of the low-energy ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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The conformational features of some glycine-monosubstituted analogues of neurokinins A and B were investigated by the method of theoretical conformational analysis. The calculated geometry and energy parameters permitted one to determine the structural role of each of these substituted amino acids in the mechanism of folding of the low-energy ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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Structure-Activity Relationships of Neurokinin A and B
1987Neurokinin A (NKA) and neurokinin B (NKB) are newly discovered mammalian neuropeptides, the chemical structures of which are closely related to tachykinin peptides (1). Both neurokinins have qualitatively the same pharmacological properties, such as contraction of smooth muscles, hypotensive effect and salivation (2).
E. Munekata +3 more
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