Results 41 to 50 of about 1,032,345 (337)

Calcineurin Is Universally Involved in Vesicle Endocytosis at Neuronal and Nonneuronal Secretory Cells

Cell Reports, 2014
Calcium influx triggers and accelerates endocytosis in nerve terminals and nonneuronal secretory cells. Whether calcium/calmodulin-activated calcineurin, which dephosphorylates endocytic proteins, mediates this process is highly controversial for ...
Xin-Sheng Wu, Zhen Zhang, Wei-Dong Zhao, Dongsheng Wang, Fujun Luo, Ling-Gang Wu   +5 more
doaj   +1 more source

Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders

Biomedicines, 2022
There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
Juan Miguel Godoy-Corchuelo, Luis C. Fernández-Beltrán, Zeinab Ali, María J. Gil-Moreno, Juan I. López-Carbonero, Antonio Guerrero-Sola, Angélica Larrad-Sainz, Jorge Matias-Guiu, Jordi A. Matias-Guiu, Thomas J. Cunningham, Silvia Corrochano   +10 more
doaj   +1 more source

Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk : a prospective population study [PDF]

, 2009
Objective: To investigate whether regulatory problems, i.e., crying and feeding problems in infants > 3 months of age, predict cognitive outcome in preschool children born at risk even when controlled for confounding factors.
Alvarez, Anderson, Andrea Schreier, Anuntaseree, Arbuckle, Armstrong, Aylward, Bacharach, Bartram, Bauer, Baumeister, Becker, Becker, Beery, Beery, Bergman, Boekaerts, Bornstein, Brandt, Brandt, Braus, Breslau, Browne, Burgemeister, Burgemeister, Byrne, Böhm, Carvajal, Casaer, Casaer, Castellanos, Chatoor, Childers, Cohen, Dahl, DeGangi, DeGangi, Dieter Wolke, Dubowitz, Dunn, Egger, El-Faddagh, Frings, Gabriele Schmid, Gale, Golding, Gomez-Benito, Gray, Griffiths, Hair, Hanson, Hedegaard, Hiscock, Johnson, Khashan, Kiese, Kiese-Himmel, Klein, Klenberg, Kline, Laucht, Laucht, Laucht, Lepkin, Lindberg, Lindberg, Lindstam, Liu, Lou, Luiz, Lundqvist, Lundqvist-Persson, Marlow, McCall, McDermott, Minde, Mortensen, Nordberg, Northstone, Overman, Papousek, Papousek, Papousek, Peterson, Porges, Posner, Rao, Rees, Reijneveld, Reilly, Remschmidt, Renate Meyer, Richman, Riegel, Ryckman, Schermelleh-Engel, Scott, Skovgaard, St James-Roberts, St James-Roberts, St James-Roberts, St James-Roberts, Tabachnik, Thunström, Tirosh, Tong, Turkheimer, van der Wal, von Hofacker, von Hofacker, von Kries, Wake, Weinstock, West, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wright, Wurmser, Wurmser, Wurmser   +126 more
core   +1 more source

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model

Journal of Neuroinflammation, 2023
Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored.
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao   +9 more
doaj   +1 more source

Psychiatric manifestations of multiple sclerosis and acute disseminated encephalomyelitis [PDF]

, 2006
It is unusual for acute disseminated encephalomyelitis and multiple sclerosis to present as purely psychiatric disorders. We report five patients with such demyelinating diseases and symptoms of psychosis, depression or anxiety.
Brinar, Marko, Brinar, Vesna V., Habek, Mario, Poser, Charles M.   +3 more
core   +1 more source

Health Effects Associated With Electronic Cigarette Use: Automated Mining of Online Forums. [PDF]

, 2020
BACKGROUND:Our previous infodemiological study was performed by manually mining health-effect data associated with electronic cigarettes (ECs) from online forums.
Hristidis, Vagelis, Hua, My, Sadah, Shouq, Talbot, Prue   +3 more
core  

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Robust, atlas-free, automatic segmentation of brain MRI in health and disease

Heliyon, 2019
Background: Brain- and lesion-volumes derived from magnetic resonance images (MRI) serve as important imaging markers of disease progression in neurodegenerative diseases and aging.
Kartiga Selvaganesan, Emily Whitehead, Paba M. DeAlwis, Matthew K. Schindler, Souheil Inati, Ziad S. Saad, Joan E. Ohayon, Irene C.M. Cortese, Bryan Smith, Steven Jacobson, Avindra Nath, Daniel S. Reich, Sara Inati, Govind Nair   +13 more
doaj   +1 more source

Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Stem Cell Research & Therapy, 2023
In the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts.
Hao Yang, Yuan Yang, Fedir N. Kiskin, Mengcheng Shen, Joe Z. Zhang   +4 more
doaj   +1 more source