Results 101 to 110 of about 8,760 (227)
Frontiers in Neurology, 2019 Differentiating early-stage Parkinson's disease (PD) from essential tremor (ET) remains challenging. In the current study, we aimed to evaluate whether visual analyses of neuromelanin-sensitive magnetic resonance imaging (NM-MRI) combined with nigrosome ...
Lirong Jin +16 more
doaj +1 more source
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration [PDF]
, 2014 Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons.
Budhu, Sadna +12 more
core +3 more sources
Molecules, 2014 Neuromelanin (NM) is produced in dopaminergic neurons of the substantia nigra (SN) and in noradrenergic neurons of the locus coeruleus (LC). The synthesis of NM in those neurons is a component of brain aging and there is the evidence that this pigment ...
Kazumasa Wakamatsu +6 more
doaj +1 more source
New MRI diagnostic methods in Parkinson's disease: evaluating nigral degeneration
Анналы клинической и экспериментальной неврологии, 2019 Research Center of Neurology, Moscow, Russia Parkinson's disease (PD) is a progressive neurodegenerative disorder with a characteristic pathological hallmark of loss of the dopaminergic neurons in the compact part of the substantia nigra in the ...
Sergey N. Illarioshkin +3 more
doaj +1 more source
Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. [PDF]
, 2004 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra.
Asanuma, Masato +3 more
core +1 more source
Pigmented Ependymoma With Lipofuscin and Neuromelanin Production
Archives of Pathology & Laboratory Medicine, 2003 Abstract We report an unusual case of ependymoma with pigmentation, a phenomenon that has only been described in a few cases, to our knowledge. This tumor occurred in the fourth ventricle of a 45-year-old man. It showed the typical histologic appearance of ependymoma with perivascular pseudorosettes and rare ependymal rosettes.
Alexander Chak Lam, Chan +3 more
openaire +2 more sources
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]
, 2015 Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa +14 more
core +4 more sources
C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]
, 2008 Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper +38 more
core +8 more sources
EPR investigations of the iron domain in neuromelanin
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1997 The interactions between iron and neuromelanin (NM) have been studied by means of EPR spectroscopy. The variable temperature EPR spectral features of a specimen of NM extracted from normal human midbrains clearly indicate that iron is present as polynuclear oxy-hydroxy ferric aggregates as well as isolated Fe(III) centres. Ferric oxy-hydroxy phases are
AIME, Silvio +6 more
openaire +5 more sources
Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease
Frontiers in Aging Neuroscience, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias +9 more
doaj +1 more source