Results 91 to 100 of about 8,760 (227)
Nature Communications, 2019 It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent ...
Iria Carballo-Carbajal +15 more
doaj +1 more source
NeuroImage: Clinical, 2020 Background: To date there are no validated MRI biomarkers to assist diagnosis of Parkinson’s disease (PD). Our aim was to investigate PD related iron changes in the substantia nigra pars compacta (SNpc) as defined by neuromelanin-sensitive MR contrast ...
Naying He +7 more
doaj +1 more source
Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]
, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
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Attenuated pupillary response during visual search in preclinical Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION The locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task‐evoked pupil dilation provides an index of locus coeruleus–norepinephrine function that might be altered in cognitively normal older adults with underlying ...
Elena K. Festa +7 more
wiley +1 more source
Toxins, 2017 The implication of the cyanotoxin β-N-methylamino-l-alanine (BMAA) in long-lasting neurodegenerative disorders is still a matter of controversy. It has been alleged that chronic ingestion of BMAA through the food chain could be a causative agent of ...
Nicolas Delcourt +4 more
doaj +1 more source
Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates [PDF]
, 2009 In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates (2-S-GSH-DA-o-quinone and 5-S-GSH-DA-o-quinone).
Tit Meng Lim, Zhidong Zhou
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Melanin and Nicotine: A Review of the Literature [PDF]
, 2006 The role of melanin in nicotine uptake and metabolism has received little attention. Because nicotine has been shown to accumulate in tissues containing melanin, exploring links between melanin and nicotine may provide additional clues to understanding ...
Malone, Ruth, Yerger, Valerie
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CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.In MPTP‐treated mice, DKI and 1H‐MRS revealed increased hippocampal and thalamic diffusivity with reduced striatal Glu/tCr and Glx/tCr at 24 h. By 72 h, cortical, striatal, and thalamic diffusivity rose, with partial hippocampal recovery. Elevated Tau/tCr and hippocampal metabolite alterations paralleled neuronal loss and gliosis, supporting DKI/1H‐MRS
Ajay Modi +10 more
wiley +1 more source
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
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Magnetic investigations of human mesencephalic neuromelanin
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002 Pigmentation of neurons in substantia nigra is due to neuromelanin, a pigment that stores large amounts of iron. Human mesencephalic neuromelanin has been investigated by means of magnetic susceptibility measurements as a function of temperature. Magnetic measurements provide a physico-chemical characterization of the iron cluster buried in the organic
BOLZONI F +5 more
openaire +4 more sources