Results 111 to 120 of about 8,760 (227)
[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia [PDF]
, 2018 Introduction Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology.
Aigbirhio, Franklin +12 more
core +1 more source
Toxicty of a Serotonin-derived Neuromelanin [PDF]
, 2010 Neuroscience - Vision and Functional Brain Imaging Poster SessionIntroduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e ...
Fibuch, Eugene +2 more
core
Towards Structure-Property-Function Relationships for Eumelanin
, 2005 We discuss recent progress towards the establishment of important structure-property-function relationships in eumelanins - key functional bio-macromolecular systems responsible for photo-protection and immune response in humans, and implicated in the ...
Ben J. Powell +46 more
core +1 more source
Neural Regeneration Research, 2014 Idiopathic Parkinson's disease (IPD) is a progressive, neurodegenerative movement disorder characterized by bradykinesia, muscular rigidity, postural instability and tremor. IPD is usually diagnosed based on clinical findings, but diagnoses are only 75–90% accurate when compared with autopsy results.
Nakamura, Ken, Sugaya, Keizo
openaire +2 more sources
EJNMMI ResearchBackground Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurological diseases.
Hongyan Feng +7 more
doaj +1 more source
PLoS ONE, 2023 Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a
Yuening Luo, Kazuichi Sakamoto
doaj
Brain organoids and insights on human evolution. [PDF]
, 2019 Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions.
Muotri, Alysson R
core
, 2018 Pathological iron accumulation in the human brain is a biomarker for neurodegeneration. Several diagnostically promising MR- based methods for in vivo iron quantification were proposed, based on the empirical relationship between R 2 * and iron ...
Arendt, T. +8 more
core
Environmental Toxins Linked to Neurodegeneration and Autism Activate the Brain’s Immune System [PDF]
, 2012 Microglia are the primary immune cells of the central nervous system and become activated in response to noxious stimuli, leading to a cycle of inflammation and cell death that has been implicated in the development of Parkinson’s disease and autism ...
Hill, J. L. +6 more
core +1 more source