Measuring Neuromuscular Junction Functionality [PDF]
Journal of Visualized Experiments, 2017 Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS). Here we describe an experimental protocol that can be used to measure NMJ functionality by combining two types of electrical stimulation ...
Rizzuto, Emanuele +4 more
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A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]
Neural Development, 2008 Background The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Smyth Neil +3 more
doaj +6 more sources
Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis [PDF]
BMC Pharmacology and ToxicologyBackground Myasthenia gravis is a rare autoimmune disease mediated by autoantibodies directed against acetylcholine receptors (AChRs) at the neuromuscular junction.
Baehyun Shin +7 more
doaj +2 more sources
A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis [PDF]
npj Systems Biology and ApplicationsA molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process.
V. A. Shiva Ayyadurai +2 more
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Age-Dependent Regulation of Acetylcholine Release at the Neuromuscular Junction Mediated by GABA. [PDF]
CellsNevsky E +5 more
europepmc +3 more sources
Frontiers in Immunology, 2022 IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang +10 more
doaj +1 more source
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. [PDF]
PLoS ONE, 2012 The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately ...
Emilie Audouard +7 more
doaj +1 more source
Myasthenia gravis in clinical practice
Arquivos de Neuro-Psiquiatria, 2022 Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease.
Eduardo de Paula Estephan +2 more
doaj +1 more source
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications, 2022 The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in
Seok-Ting J. Ang +10 more
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Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
doaj +1 more source