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Autoimmune Channelopathies at Neuromuscular Junction [PDF]
Frontiers in Neurology, 2019 The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal transmission, such as voltage-gated calcium channels and voltage-gated potassium channels on presynaptic
Kun Huang +3 more
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The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease [PDF]
International Journal of Molecular Sciences, 2021 The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating in the motor neuron to action potentials in the muscle fiber. The consideration of contributing factors to skeletal muscle injury, muscular dystrophy and sarcopenia cannot
Shama R. Iyer +2 more
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Reconstruction of the neuromuscular junction connectome [PDF]
Bioinformatics, 2010 Abstract Motivation: Unraveling the structure and behavior of the brain and central nervous system (CNS) has always been a major goal of neuroscience. Understanding the wiring diagrams of the neuromuscular junction connectomes (full connectivity of nervous system neuronal components) is a starting point for this, as it helps in the study
Srinivasan, Ranga +5 more
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Diseases of the neuromuscular junction
Current Opinion in Pharmacology, 2002 The neuromuscular junction is a prototype synapse and it is also the site of well-characterised autoimmune and hereditary disorders. In the presynaptic terminal, voltage-gated potassium channels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the enzyme that synthesises acetylcholine have been demonstrated in
McConville, J, Vincent, A
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DOXAPRAM AND THE NEUROMUSCULAR JUNCTION †
British Journal of Anaesthesia, 1989 We have studied the action of doxapram on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation. Doxapram augmented neuromuscular transmission in a dose-related manner when a threshold concentration of 5 x 10(-5) mol litre-1 had been exceeded.
Barbara J. Pleuvry +2 more
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Neuromuscular Junction Disorders
DeckerMed Medicine, 2002 The three main components of the neuromuscular junction (NMJ) include the presynaptic region, the synaptic cleft, and the postsynaptic region. The NMJ acts as an interface between the motor nerve and muscle by converting the motor nerve electric currents into chemical signals and then back into electric currents in the muscle.
Mohammad Salajegheh, Anthony A. Amato
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THE NEUROMUSCULAR JUNCTION DISORDERS [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2003 Neuromuscular junction (NMJ) disorders result from destruction, malfunction or absence of one or more key proteins involved in neuromuscular transmission, illustrated diagrammatically in fig 1. The most common pathology is antibody mediated damage or down regulation of ion channels or receptors, resulting in myasthenia gravis (MG), Lambert-Eaton ...
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SnapShot: Neuromuscular Junction
Cell, 2011 Agrin MuSK Dok-7Rapsyn AChR AChE ChAT Nav1.4Auto-antibodiesto AChRsAuto-antibodiesto MuSKHypomorphic mutations in thesegenes impair postsynaptic differentiation. The number of AChRs at synapses is reduced, which compromises the reliability of synaptic transmission and leads to muscle weakness and fatigue.
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Measuring Neuromuscular Junction Functionality [PDF]
Journal of Visualized Experiments, 2017 Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS). Here we describe an experimental protocol that can be used to measure NMJ functionality by combining two types of electrical stimulation ...
Simona Pisu +6 more
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The Neuromuscular Junction [PDF]
Journal of Neuropathology and Experimental Neurology, 1985 Hassan H. Ali, Edward Lowenstein
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