Results 1 to 10 of about 77,782 (191)

Measuring neuromuscular junction functionality [PDF]

, 2017
Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS).
Del Prete, Zaccaria, Musaro, Antonio, Nicoletti, Carmine, Pisu, Simona, Rizzuto, Emanuele   +4 more
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A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]

, 2008
Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Fox, Michael A., Ho, Matthew S.P., Sanes, Joshua R., Smyth, Neil   +3 more
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CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
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Mathematical modeling of the Drosophila neuromuscular junction [PDF]

, 2009
Poster presentation: An important challenge in neuroscience is understanding how networks of neurons go about processing information. Synapses are thought to play an essential role in cellular information processing however quantitative and mathematical ...
Bucher, Daniel, Knodel, Markus Michael, Queisser, Sean Gillian, Schuster, Christoph M., Wittum, Gabriel   +4 more
core   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction [PDF]

, 2011
The neuromuscular junction has been extensively employed in order to identify crucial determinants of synaptogenesis. At the vertebrate neuromuscular synapse, extracellular matrix and signaling proteins play stimulatory and inhibitory roles on the ...
Aberle, Ahmad-Annuar, An, Anitha, Ataman, Avila, Ball, Bayat, Bowe, Bragdon, Cadigan, Carlson, Catherine E. Krull, De Robertis, DeChiara, Dion, Eaton, Enzmann, Estevez, Fallon, Fallon, Farias, Fassier, Feng, Flanagan-Steet, Foletta, Fox, Fox, Franco, Fuentealba, Gautam, Gilboa, Glass, Gordon, Gratacos, He, Henriquez, Hirth, Horbinski, Inoue, Ishikawa, Iwasaki, James, Jing, Juan P. Henríquez, Kawano, Kim, Kim, Kishigami, Klassen, Kobune, Krylova, Kuhl, Kummer, Lee-Hoeflich, Lefebvre, Li, Lin, Lin, Lin, Linnoila, Logan, Luo, Macdonald, Machado, Marques, Marques, Mathew, Matsuura, Matsuura, Matthews, McCabe, McCabe, McEwen, Miech, Misgeld, Misgeld, Miyazono, Nelson Osses, Nishimune, Nitkin, Noakes, Nohe, Nohe, Okada, Okuyama, Packard, Packard, Panzer, Parikh, Podkowa, Ponomareva, Pun, Rawson, Sahni, Salinas, Salinas, Sanes, Sanes, Semenov, Setoguchi, Setoguchi, Sheldahl, Shi, Sieber, Silver, Tsang, Urist, Valenzuela, Varela-Nallar, Vock, Wallace, Wang, Wang, Weston, Weston, Wharton, Wozney, Wu, Xiao, Yabe, Yang, Zhang, Zhao   +123 more
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Mutations in the Mitochondrial Citrate Carrier SLC25A1 are Associated with Impaired Neuromuscular Transmission. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Congenital myasthenic syndromes are rare inherited disorders characterized by fatigable weakness caused by malfunction of the neuromuscular junction.
Abicht, Angela, Beeson, David, Bushby, Kate, Chaouch, Amina, Cossins, Judith, Cox, Daniel, De Grassi, Anna, Edvardson, Shimon, Elpeleg, Orly, Evangelista, Teresinha, Griffin, Helen, Horvath, Rita, Huebner, Angela, Laval, Steven H, Lochmüller, Hanns, Müller, Juliane S, Palace, Jacqueline, Palmieri, Luigi, Pierri, Ciro L, Porcelli, Vito, Scarcia, Pasquale, Senderek, Jan, Straub, Volker, Töpf, Ana, von der Hagen, Maja   +24 more
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Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J., Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Lane, Fiona M., Powis, Rachael A., Sherman, Diane L., Shorrock, Hannah K., Zheng, Yinan   +9 more
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The Aging Neuromuscular System and Motor Performance [PDF]

, 2016
Age-related changes in the basic functional unit of the neuromuscular system, the motor unit, and its neural inputs have a profound effect on motor function, especially among the expanding number of old (older than ∼60 yr) and very old (older than ∼80 yr)
Hunter, Sandra K., Keenan, Kevin, Pereira, Hugo M.   +2 more
core   +2 more sources

A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells [PDF]

, 2012
Human primary muscle cells cultured aneurally in monolayer rarely contract spontaneously because, in the absence of a nerve component, cell differentiation is limited and motor neuron stimulation is missing(1). These limitations hamper the in vitro study
Arnold, Anne-Sophie, Christe, Martine, Handschin, Christoph   +2 more
core   +1 more source