Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission [PDF]
Cells, 2019 Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last.
Maria Nicol Colombo, Maura Francolini
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Autoimmune Channelopathies at Neuromuscular Junction [PDF]
Frontiers in Neurology, 2019 The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal ...
Kun Huang +3 more
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Upregulation of Sarcolemmal Hemichannels and Inflammatory Transcripts with Neuromuscular Junction Instability during Lower Limb Unloading in Humans [PDF]
Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster [PDF]
Open Biology, 2023 Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function.
Virender K. Sahota +6 more
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Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging
Cells, 2020 Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou +1 more
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Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
eLife, 2017 Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu +10 more
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A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]
Neural Development, 2008 Background The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Smyth Neil +3 more
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Reconstruction of the neuromuscular junction connectome [PDF]
Bioinformatics, 2010 Motivation: Unraveling the structure and behavior of the brain and central nervous system (CNS) has always been a major goal of neuroscience. Understanding the wiring diagrams of the neuromuscular junction connectomes (full connectivity of nervous system
Ranga Srinivasan +5 more
semanticscholar +5 more sources
Measuring neuromuscular junction functionality [PDF]
Journal of Visualized Experiments, 2017 Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS).
Del Prete, Zaccaria +4 more
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Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction [PDF]
Physiological ReportsSarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal muscle mass and function. Originally defined as an age‐associated condition, sarcopenia presently also encompasses muscular atrophy due to various pathological ...
Yanmei Miao +7 more
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