Results 1 to 10 of about 98,850 (323)
Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging [PDF]
Cells, 2020 Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou +1 more
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A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis [PDF]
npj Systems Biology and ApplicationsA molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process.
V. A. Shiva Ayyadurai +2 more
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Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction [PDF]
Physiological ReportsSarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal muscle mass and function. Originally defined as an age‐associated condition, sarcopenia presently also encompasses muscular atrophy due to various pathological ...
Yanmei Miao +7 more
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From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease [PDF]
Journal of Tissue EngineeringPeripheral neuropathies are disorders affecting the peripheral nervous system. Among them, Charcot-Marie-Tooth disease is an inherited sensorimotor neuropathy for which no effective treatment exists yet.
Camille Scherrer +9 more
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Taiwanese Journal of Obstetrics & Gynecology, 2012 Fetal akinesia deformation sequence is a clinically and genetically heterogeneous disorder characterized by a variable combination of arthrogryposis, fetal akinesia, intrauterine growth restriction, developmental abnormalities such as cystic hygroma ...
Chih-Ping Chen
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Frontiers in Immunology, 2022 IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang +10 more
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The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. [PDF]
PLoS ONE, 2012 The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately ...
Emilie Audouard +7 more
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Myasthenia gravis in clinical practice
Arquivos de Neuro-Psiquiatria, 2022 Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease.
Eduardo de Paula Estephan +2 more
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Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications, 2022 The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in
Seok-Ting J. Ang +10 more
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Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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