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Autoimmune Channelopathies at Neuromuscular Junction [PDF]
Frontiers in Neurology, 2019 The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal ...
Kun Huang +3 more
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Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging
Cells, 2020 Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou +1 more
doaj +2 more sources
Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
eLife, 2017 Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu +10 more
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A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis [PDF]
npj Systems Biology and ApplicationsA molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process.
V. A. Shiva Ayyadurai +2 more
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Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission
Cells, 2019 Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last.
Maria Nicol Colombo, Maura Francolini
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The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease [PDF]
International Journal of Molecular Sciences, 2021 The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating in the motor neuron to action potentials in the muscle fiber.
S. Iyer, Sameer B. Shah, R. Lovering
semanticscholar +3 more sources
Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction [PDF]
Physiological ReportsSarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal muscle mass and function. Originally defined as an age‐associated condition, sarcopenia presently also encompasses muscular atrophy due to various pathological ...
Yanmei Miao +7 more
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Frontiers in Immunology, 2022 IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang +10 more
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Journal of Physiology, 2021 Few days of unloading are sufficient to induce a decline of skeletal muscle mass and function; notably, contractile force is lost at a faster rate than muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood.
E. Monti +16 more
semanticscholar +1 more source
Nature Communications, 2021 Mislocalization of the predominantly nuclear RNA/DNA binding protein, TDP-43, occurs in motor neurons of ~95% of amyotrophic lateral sclerosis (ALS) patients, but the contribution of axonal TDP-43 to this neurodegenerative disease is unclear.
Topaz Altman +15 more
semanticscholar +1 more source