Results 11 to 20 of about 615,784 (234)

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

eLife, 2017
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal   +10 more
doaj   +2 more sources

Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging

Cells, 2020
Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou, Russell T. Hepple   +1 more
doaj   +2 more sources

Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission

Cells, 2019
Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last.
Maria Nicol Colombo, Maura Francolini
doaj   +2 more sources

A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis. [PDF]

NPJ Syst Biol Appl
A molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework for organizing complexity of biomolecular interactions in amyotrophic lateral sclerosis (ALS) using a systematic literature review process.
Ayyadurai VAS, Deonikar P, Kamm RD.
europepmc   +2 more sources

Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction. [PDF]

Physiol Rep
Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal muscle mass and function. Originally defined as an age‐associated condition, sarcopenia presently also encompasses muscular atrophy due to various pathological ...
Miao Y, Xie L, Song J, Cai X, Yang J, Ma X, Chen S, Xie P.   +7 more
europepmc   +2 more sources

Neuromuscular junction dysfunctions due to immune checkpoint inhibitors therapy: An analysis of FAERS data in the past 15 years

Frontiers in Immunology, 2022
IntroductionThe adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics.ObjectiveTo assess the neuromuscular junction dysfunctions in cancer patients with ...
Ping Zhang, Donghui Lao, Haoyan Chen, Bin Zhao, Qiong Du, Qiong Du, Qing Zhai, Qing Zhai, Xuan Ye, Xuan Ye, Bo Yu   +10 more
doaj   +1 more source

Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans

Journal of Physiology, 2021
Few days of unloading are sufficient to induce a decline of skeletal muscle mass and function; notably, contractile force is lost at a faster rate than muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood.
E. Monti, C. Reggiani, M. Franchi, L. Toniolo, M. Sandri, A. Armani, S. Zampieri, E. Giacomello, F. Sarto, Giuseppe Sirago, M. Murgia, L. Nogara, L. Marcucci, Stefano Ciciliot, B. Šimunič, R. Pišot, M. Narici   +16 more
semanticscholar   +1 more source

Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins

Nature Communications, 2021
Mislocalization of the predominantly nuclear RNA/DNA binding protein, TDP-43, occurs in motor neurons of ~95% of amyotrophic lateral sclerosis (ALS) patients, but the contribution of axonal TDP-43 to this neurodegenerative disease is unclear.
Topaz Altman, A. Ionescu, Amjad Ibraheem, Dominik Priesmann, Tal Gradus-Pery, Luba Farberov, Gayster Alexandra, N. Shelestovich, R. Dafinca, N. Shomron, F. Rage, K. Talbot, Michael E. Ward, A. Dori, M. Krüger, E. Perlson   +15 more
semanticscholar   +1 more source

Neuromuscular junction dysfunction in Lafora disease.

Dis Model Mech
Shukla M, Chugh D, Ganesh S.
europepmc   +2 more sources

Terminal Schwann cells at the human neuromuscular junction

Brain Communications, 2021
Terminal Schwann cells are non-myelinating glial cells localized to the neuromuscular junction. They play an important role in regulating many aspects of neuromuscular junction form and function, in health and during disease. However, almost all previous
Abrar Alhindi, I. Boehm, R. Forsythe, Janice Miller, R. Skipworth, H. Simpson, Ross A. Jones, T. Gillingwater   +7 more
semanticscholar   +1 more source