Results 11 to 20 of about 100,070 (325)

Plum modulates Myoglianin and regulates synaptic function in D. melanogaster

Open Biology, 2023
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function.
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin   +6 more
doaj   +1 more source

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

eLife, 2017
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal   +10 more
doaj   +1 more source

Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Chronic obstructive pulmonary disease (COPD) patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity.
Trace Thome, Kayla Miguez, Alexander J. Willms, Sarah K. Burke, Vijayendran Chandran, Angela R. deSouza, Liam F. Fitzgerald, Carolyn Baglole, Maria‐Eleni Anagnostou, Jean Bourbeau, R. Thomas Jagoe, Jose A. Morais, Yana Goddard, Tanja Taivassalo, Terence E. Ryan, Russell T. Hepple   +15 more
doaj   +1 more source

Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis

Neural Regeneration Research, 2021
Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the ...
Francisco J Barrantes
doaj   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

Frontiers in Molecular Neuroscience, 2022
Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies.
Xinying Huang, Xinying Huang, Xinying Huang, Xinying Huang, Junjian Jiang, Junjian Jiang, Junjian Jiang, Jianguang Xu, Jianguang Xu, Jianguang Xu   +9 more
doaj   +1 more source

Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates. [PDF]

PLoS Biol
Hossain MF, Popsuj S, Vitrinel B, Kaplan NA, Stolfi A, Christiaen L, Ruggiu M.   +6 more
europepmc   +2 more sources

Autoimmune Channelopathies at Neuromuscular Junction

Frontiers in Neurology, 2019
The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal ...
Kun Huang, Kun Huang, Yue-Bei Luo, Huan Yang   +3 more
doaj   +1 more source

Neuromuscular junction dysfunction in Lafora disease

Disease Models & Mechanisms
Monica Shukla, Deepti Chugh, Subramaniam Ganesh   +2 more
doaj   +2 more sources

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J., Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Lane, Fiona M., Powis, Rachael A., Sherman, Diane L., Shorrock, Hannah K., Zheng, Yinan   +9 more
core   +3 more sources