Results 21 to 30 of about 615,784 (234)
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. [PDF]
PLoS ONE, 2012 The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately ...
Emilie Audouard +7 more
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Myasthenia gravis in clinical practice
Arquivos de Neuro-Psiquiatria, 2022 Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease.
Eduardo de Paula Estephan +2 more
doaj +1 more source
Biology, 2023 Human skeletal muscle atrophy and a disproportionate force loss occur within a few days of unloading in space and on Earth, but the underlying mechanisms are not fully understood.
Giuseppe Sirago +13 more
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Frontiers in Molecular Neuroscience, 2020 The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron nerve terminal and its muscle fiber that are responsible for converting electrical impulses generated by the motor neuron into electrical activity in the muscle ...
P. M. Rodríguez Cruz +3 more
semanticscholar +1 more source
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
Nature Communications, 2022 The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in
Seok-Ting J. Ang +10 more
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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster
Open Biology, 2023 Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function.
Virender K. Sahota +6 more
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Comparative anatomy of the mammalian neuromuscular junction
Journal of Anatomy, 2020 The neuromuscular junction (NMJ)—a synapse formed between lower motor neuron and skeletal muscle fibre—represents a major focus of both basic neuroscience research and clinical neuroscience research. Although the NMJ is known to play an important role in
I. Boehm +12 more
semanticscholar +1 more source
Neural Regeneration Research, 2021 Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the ...
Francisco J Barrantes
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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
Nature Communications, 2020 With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes skeletal muscle hypertrophy, but also drives organismal aging.
D. J. Ham +17 more
semanticscholar +1 more source
Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Chronic obstructive pulmonary disease (COPD) patients exhibit skeletal muscle atrophy, denervation, and reduced mitochondrial oxidative capacity.
Trace Thome +15 more
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