Results 91 to 100 of about 32,201 (250)

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

Immunopathogenesis of Neuromyelitis Optica

, 2014
Neuromyelitis optica (NMO, Devic's syndrome) is a clinical syndrome characterized by optic neuritis and (mostly longitudinally extensive) myelitis. If untreated, NMO usually takes a relapsing course and often results in blindness and tetra- or paraparesis. The discovery of autoantibodies to aquaporin-4, the most abundant water channel in the CNS, in 70-
Levy, Michael, Wildemann, Brigitte, Jarius, Sven, Orellano, Benjamine, Sasidharan, Saranya, Weber, Martin S., Stuve, Olaf   +6 more
openaire   +4 more sources

Improved UNet‐based magnetic resonance imaging segmentation of demyelinating diseases with small lesion regions

Cognitive Computation and Systems, EarlyView.
Abstract Accurate magnetic resonance imaging (MRI) segmentation plays a critical role in the diagnosis and treatment of demyelinating diseases. But the existing automatic segmentation methods are not suitable for the segmentation of demyelinating lesions with small lesion size, highly diffuse edges and complex boundary shapes.
Minhui Liu, Tianlei Wang, Dekang Liu, Feng Gao, Jiuwen Cao   +4 more
wiley   +1 more source

Clinical, outcome and aetiological chacteristics of inflammatory optic neuropathies. A series of Algerian patients. [PDF]

Batna Journal of Medical Sciences
Introduction. Inflammatory optic neuropathies (ION) are frequent neuroophthalmological emergencies. They often pose an etiological problem. Objectives. To study the clinical, radiological, etiological and evolutionary particularities of ION in Algerian
Mohamed Islam KEDIHA, Dalila MOUALEK, Farida MOSTEFAOUI, Lamia ALI PACHA   +3 more
doaj   +1 more source

Objektivierung von funktionellen und strukturellen Beeinträchtigungen sensorischer Afferenzen bei neuroimmunologischen Krankheitsbildern [PDF]

, 2020
In dieser kumulativen Habilitationsschrift werden eigene Arbeiten zusammengefasst, die sich thematisch mit der Objektivierung sensorischer Afferenzstörungen bei neuroimmunologischen Krankheitsbildern befassen. B-mode Ultraschall, eine in der klinischen
Schmidt, Felix Alexander
core   +1 more source

B lymphocytes in neuromyelitis optica [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4).
Bennett, Jeffrey L., O'Connor, Kevin C., Bar-Or, Amit, Zamvil, Scott S., Hemmer, Bernhard, Tedder, Thomas F., von Büdingen, H-Christian, Stuve, Olaf, Yeaman, Michael R., Smith, Terry J., Stadelmann, Christine   +10 more
openaire   +5 more sources

Effect of time to initiation and dose of methylprednisolone on outcome in multiple sclerosis‐related optic neuritis

Clinical and Experimental Neuroimmunology, EarlyView.
Abstract Objectives It is known that the benefit of intravenous methylprednisolone (IVMP) in multiple sclerosis‐related optic neuritis (MS‐ON) is limited to an accelerated recovery. We aimed to evaluate the impact of time from symptoms onset to IVMP initiation and of IVMP dose on visual recovery among people with MS‐ON.
Hadar Gilad, Josepha Horowitz, Sivan Bloch, Daniel Golan   +3 more
wiley   +1 more source

Impact of Symptoms of Neuromyelitis Optica Spectrum Disorder and Patient‐Determined Oral Glucocorticoid–Related Adverse Events on Patients' Daily Living and Emotions: A Qualitative Analysis From Japan

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Background and Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a chronic disorder with a relapsing–remitting disease course that impacts patients' quality of life. Oral glucocorticoids (OGCs) have been the standard of care for NMOSD in Japan; however, their chronic use is associated with adverse events (AEs).
Yuko Shimizu, Ichiro Nakashima, Ryotaro Ikeguchi, Tadashi Nagatsuka, Katsuhisa Yamashita, Yuta Fukuoka, Tatsunori Murata, Kazuo Fujihara   +7 more
wiley   +1 more source

Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome [PDF]

, 2016
Background A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG).
Asgari, Nasrin, Borisow, Nadja, Jarius, Sven, Kleiter, Ingo, Pache, Florence [u. v. m.], Pitarokoili, Kalliopi, Ruprecht, Klemens   +6 more
core   +1 more source

Recent Progress in Double Filtration Plasmapheresis

Hemodialysis International, EarlyView.
ABSTRACT Double‐filtration plasmapheresis is an advanced extracorporeal blood purification technique that selectively removes pathogenic macromolecules based on molecular weight. Unlike conventional plasma exchange, double‐filtration plasmapheresis uses a two‐step filtration process to retain beneficial plasma components such as albumin, while ...
Dan Li, Xiaoqiang Liu, Yuhan Wang, Wenxuan Ji   +3 more
wiley   +1 more source