Neuromyelitis Optica Spectrum Disorders: Clinical Perspectives, Molecular Mechanisms, and Treatments
Applied Sciences, 2023 Neuromyelitis optica (NMO) is a rare autoimmune inflammatory disorder affecting the central nervous system (CNS), specifically the optic nerve and the spinal cord, with severe clinical manifestations, including optic neuritis (ON) and transverse myelitis.
Subramanian Thangaleela +4 more
doaj +1 more source
Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. [PDF]
, 2014 Background Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water ...
Asavapanumas, N +6 more
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Child Neurology: Neuromyelitis optica spectrum disorders [PDF]
Neurology, 2017 A 3-year-old girl presented with 4 days of progressive bilateral vision loss. Medical history included presumed autoimmune hepatitis at 6 months of age, when she had an extensive evaluation including hepatitis A immunoglobulin G (IgG) detected in her serum, thought to represent maternal antibodies.
Michael J, Bradshaw +3 more
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Pediatric Neuromyelitis Optica Spectrum Disorders: Three Case Reports and Review of Literature
Journal of Pediatrics Review, 2020 Introduction: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare autoimmune inflammatory and astrocytopathic demyelinating disease of the Central Nervous System (CNS). In most patients, an autoantibody to the water channel protein aquaporin-4 (AQP4)
Seyed Mohammad Baghbanian +2 more
doaj
Anti-B-cell therapy in patients with neuromyelitis optica spectrum disorders
Неврология, нейропсихиатрия, психосоматика, 2021 Neuromyelitis optica spectrum disorders (NMOSDs) are a group of central nervous system autoimmune diseases characterized by similar clinical manifestations, optic neuritis, and transverse myelitis being the most frequent among them.
S. V. Kotov, E. S. Novikova, A. S. Kotov
doaj +1 more source
Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. [PDF]
, 2019 Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this
Chang, Guoqiang +6 more
core +1 more source
Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. [PDF]
, 2017 Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies ...
Verkman, Alan S, Yao, Xiaoming
core +2 more sources
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru +13 more
wiley +1 more source
Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders [PDF]
, 2016 Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS).
Casado Chocán, José Luis +8 more
core +2 more sources