Results 61 to 70 of about 7,096 (184)
Targeted therapy for neuromyelitis optica spectrum disorders
Chinese Journal of Contemporary Neurology and Neurosurgery, 2020 Neuromyelitis optica spectrum disorders (NMOSDs) have the characteristics of high relapse rate and high disability rate. The neurological deficits would become more and more serious with increasing relapse.
Yang⁃tai GUAN
doaj
Journal of Rehabilitation Medicine, 2019 Objective: To provide detailed data on the effects of multidisciplinary rehabilitation for patients with neuromyelitis optica spectrum disorder with moderate to severe disability. Design: A pilot randomized control study.
Dong-Mei Suo +9 more
doaj +1 more source
Annals of Neurology, Volume 99, Issue 6, Page 1480-1485, June 2026.The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial ...
Jonathan A. Gernert +13 more
wiley +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
Role of Glutamatergic Excitotoxicity in Neuromyelitis Optica Spectrum Disorders
Frontiers in Cellular Neuroscience, 2019 Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disorder mediated by immune-humoral responses directed against central nervous system (CNS) antigens.
Ana Paula Bornes da Silva +6 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.ABSTRACT Background Relapse is the primary driver of irreversible disability accumulation in neuromyelitis optica spectrum disorder (NMOSD). Although aquaporin‐4 immunoglobulin G (AQP4‐IgG) is central to disease diagnosis and pathogenesis, reliable tools for individualized relapse risk stratification remain limited.
Xingyue Zheng +11 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is an autoimmune disorder characterized by demyelination of the central nervous system. It can impact the optic nerves, spinal cord, brain parenchyma, and brainstem, resulting in various clinical presentations such as acute disseminated encephalomyelitis (ADEM), optic ...
Yuxian Shi +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Optic neuritis is an acute inflammatory disease that can cause acute visual loss. We present a case of a 22‐year‐old female in postpartum with acute headache, retroocular pain, and bilateral amaurosis. Orbit MRI revealed inflammatory changes in both neurovascular optical bundles.
Jose Luis Rojas‐Oviedo +5 more
wiley +1 more source
Mediators of Inflammation, 2016 Objective. This study aimed to examine the potential role of memory T follicular helper (Tfh) cells in patients with neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD). Methods.
Xueli Fan +6 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes during NMOSD onset and relapse. The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes, thereby facilitating the release of BAFF and inflammatory cytokines (including IL‐1, IL‐6, IL‐8, and TNF‐α).
Meiqun Deng +8 more
wiley +1 more source