Results 81 to 90 of about 12,119 (223)

Hyperreflective Foci in the Inner Nuclear Layer: Proof‐of‐Concept for an Optical Coherence Tomography Derived Microglia‐Related Marker in Multiple Sclerosis

Annals of Neurology, EarlyView.
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial ...
Jonathan A. Gernert, Laura M. Bartos, Tara Christmann, Hanna Zausinger, Luca N. Diedrich, Daniel Engels, Miriam Schlüter, Sarah Schlaeger, Sophia Stoecklein, Leonie F. Keidel, Tania Kümpfel, Martin Kerschensteiner, Matthias Brendel, Joachim Havla   +13 more
wiley   +1 more source

Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination [PDF]

, 2017
Background Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum ...
Boehm, Denise, Given, Katherine, Peschl, Patrick, Ruprecht, Klemens, Saiz, Albert [u. a.], Schanda, Kathrin, Zeka, Bleranda   +6 more
core   +1 more source

With Regard to the Expression Status of Sarcolemmal Aquaporin 4 in Human Muscular Dystrophies

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Human muscular dystrophies are inherited muscle‐wasting diseases caused by the various kinds of gene mutations. Among them, Duchenne muscular dystrophy (DMD) is a representative type. Before the discovery of the causative dystrophin gene of DMD, the fragile myofiber plasma membrane was thought to be the trigger of myofiber necrosis in DMD ...
Yoshihiro Wakayama, Takahiro Jimi
wiley   +1 more source

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices [PDF]

, 2016
Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients.
A Ghezzi, A Ghezzi, A Ghezzi, A Ghezzi, A Langer-Gould, A Langer-Gould, A Rovira, A Scalfari, A Scalfari, A Waldman, AH Beecham, AJ Thompson, AK Probstel, B Banwell, B Banwell, B Banwell, B Huppke, B Kornek, BF Popescu, BT Gudbjornsson, C Lechner, C Lucchinetti, C Renoux, C Tornatore, CF Lucchinetti, CF Lucchinetti, CG Lee, CH Polman, CH Polman, CM Dalton, CM Lill, Cris S. Constantinescu, D Chabas, D Miller, DA Hafler, DH Miller, DH Miller, DM Wingerchuk, E Piscolla, EA Yeh, EA Yeh, EM Hennes, F Yang, FD Lublin, G Alper, G Bloomgren, G Filippini, H Butzkueven, Huei-Shyong Wang, I Kister, I Metz, I-Jun Chou, IA Ketelslegers, IA Ketelslegers, J Kira, J Kitley, J Kitley, J O’Mahony, J Palace, J Shimizu, JA Cohen, JK Swanton, JP Fryer, JW Peterson, K Chalmoukou, K Rostasy, KE Harding, L Belbasis, L Bo, L Kappos, L Mantia La, LB Krupp, LH Verhey, M Absinta, M Absoud, M Absoud, M Jurynczyk, M Reindl, MA Friese, MC Mayer, MF Liao, MH Barnett, MH Sun, MW Koch, N Collongues, N Heussinger, O Aktas, O Stuve, P Duquette, P Huppke, P Waters, PJ Waters, PW Schaefer, R Ali, RC Dale, RF Neuteboom, RM Ransohoff, S Bigi, S Jarius, S Lulu, S Pfeifenbring, S Ramanathan, SV Ramagopalan, T Chitnis, T Kanda, T Olsson, T Plavina, TE Lotze, William P. Whitehouse, Y Mikaeloff, Y Mikaeloff, Y Sadaka, YD Fragoso   +112 more
core   +2 more sources

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

A Rare Presentation of Neuromyelitis Optica Spectrum Disorders

Clinical Medicine Insights: Case Reports, 2018
Neuromyelitis optica spectrum disorders (NMOSDs) are a set of demyelinating disorders that primarily target the optic nerves and the spinal cord. Previously thought to be a subset of multiple sclerosis (MS), now is recognized as a distinct entity.
Navneet K Singh, Alexander J Sweidan, Sarah Strube, Ignacio Carrillo-Nunez   +3 more
doaj   +1 more source

Hypersensitivity Responses in the Central Nervous System [PDF]

, 2015
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg, Marlene Thorsen Mørch, Nasrin eAsgari, Nasrin eAsgari, Reza eKhorooshi, Trevor eOwens   +5 more
core   +4 more sources

Cognitive impairment in neuromyelitis optica spectrum disorders

Неврология, нейропсихиатрия, психосоматика
Neuromyelitis optica spectrum disorders (NMOSD) are a group of immune-mediated inflammatory lesions of the central nervous system that primarily cause dysfunction and death of astrocytes, leading to secondary disruption of myelination.
E. A. Vekhina, D. S. Kasatkin, S. E. Korchevnyi, K. I. Bereznyak   +3 more
doaj   +1 more source

Neuromyelitis optica spectrum disorders with and without connective tissue disorders

BMC Neurology, 2018
Background Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.
Chun-Sheng Yang, Qiu Xia Zhang, Sheng Hui Chang, Lin Jie Zhang, Li Min Li, Yuan Qi, Jing Wang, Zhi Hua Sun, Nannan Zhangning, Li Yang, Fu-Dong Shi   +10 more
doaj   +1 more source

Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain. [PDF]

, 2013
INTRODUCTION: Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) are present in some neuromyelitis optica patients who lack antibodies against aquaporin-4 (AQP4-IgG). The effects of neuromyelitis optica MOG-IgG in the central nervous system
PJ Waters, VA Lennon, MC Papadopoulos, SR Hinson, S Saadoun, MC Papadopoulos, M Matiello, S Jarius, G Akman-Demir, J Kitley, J Kitley, S Mader, K Rostasy, P Vourc’h, J Kitley, DK Sato, S Saadoun, S Saadoun, GP Owens, JL Bennett, D Zhou, MA Bhat, MC Mayer, CB Marta, CB Marta, DH Lee, D Zhou, GF Chernoff, M Reindl, SJ Pittock   +29 more
core   +3 more sources