Results 11 to 20 of about 470,748 (305)

HDAC1 Regulates Neuronal Differentiation [PDF]

Frontiers in Molecular Neuroscience, 2022
In adult hippocampal neurogenesis, chromatin modification plays an important role in neural stem cell self-renewal and differentiation by regulating the expression of multiple genes. Histone deacetylases (HDACs), which remove acetyl groups from histones,
Vanesa Nieto-Estevez, Vanesa Nieto-Estevez, Gopakumar Changarathil, Gopakumar Changarathil, Adebayo Olukayode Adeyeye, Adebayo Olukayode Adeyeye, Marissa Olga Coppin, Marissa Olga Coppin, Rawan Serena Kassim, Rawan Serena Kassim, Jingfei Zhu, Jenny Hsieh, Jenny Hsieh   +12 more
doaj   +3 more sources

Transferrin Enhances Neuronal Differentiation

ASN Neuro, 2023
Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse neuroblastoma cell line which, once
María Julia Pérez, Tomas Roberto Carden, Paula Ayelen dos Santos Claro, Susana Silberstein, Pablo Martin Páez, Veronica Teresita Cheli, Jorge Correale, Juana M. Pasquini   +7 more
doaj   +4 more sources

Role of Prion protein-EGFR multimolecular complex during neuronal differentiation of human dental pulp-derived stem cells [PDF]

, 2018
Cellular prion protein (PrPC) is expressed in a wide variety of stem cells in which regulates their self-renewal as well as differentiation potential. In this study we investigated the presence of PrPCin human dental pulp-derived stem cells (hDPSCs) and ...
Manganelli, Valeria, Martellucci, Stefano, Mattei, Vincenzo, Piccoli, Luca, Santacroce, Costantino, Santilli, Francesca, Sorice, Maurizio   +6 more
core   +1 more source

Differentiating lower motor neuron syndromes [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2016
Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron ...
Garg, N, Park, SB, Vucic, S, Yiannikas, C, Spies, J, Howells, J, Huynh, W, Matamala, JM, Krishnan, AV, Pollard, JD, Cornblath, DR, Reilly, MM, Kiernan, MC   +12 more
openaire   +3 more sources

Characterization of the EM66 Biomarker in the Pituitary and Plasma of Healthy Subjects With Different Gonadotroph Status and Patients With Gonadotroph Tumor

Frontiers in Endocrinology, 2019
Granins and their derived-peptides are useful markers of secretion from normal and tumoral neuroendocrine cells. The need to identify new diagnostic markers for neuroendocrine tumors, including pituitary tumors prompted us to determine plasma levels of ...
Johann Guillemot, Marlène Guérin, Anne-Françoise Cailleux, Antoine-Guy Lopez, Jean-Marc Kuhn, Youssef Anouar, Laurent Yon   +6 more
doaj   +1 more source

Modeling the functional genomics of autism using human neurons. [PDF]

, 2012
Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation,
Chen, L, Gao, F, Gao, K, Geschwind, DH, Konopka, G, Lowe, JK, Lu, D, Mukamel, Z, Osborn, GE, Rosen, E, Wexler, E   +10 more
core   +1 more source

The neuropeptide 26RFa in the human gut and pancreas: potential involvement in glucose homeostasis

Endocrine Connections, 2019
Objective: Recent studies performed in mice revealed that the neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity.
Gaëtan Prévost, Marie Picot, Marie-Anne Le Solliec, Arnaud Arabo, Hind Berrahmoune, Mouna El Mehdi, Saloua Cherifi, Alexandre Benani, Emmanuelle Nédélec, Françoise Gobet, Valéry Brunel, Jérôme Leprince, Hervé Lefebvre, Youssef Anouar, Nicolas Chartrel   +14 more
doaj   +1 more source

Eel Kisspeptins: Identification, Functional Activity, and Inhibition on both Pituitary LH and GnRH Receptor Expression

Frontiers in Endocrinology, 2018
The European eel (Anguilla anguilla) presents a blockade of sexual maturation at a prepubertal stage due to a deficient production of gonadotropins.
Jérémy Pasquier, Anne-Gaëlle Lafont, Florian Denis, Benjamin Lefranc, Christophe Dubessy, Antonio Moreno-Herrera, Antonio Moreno-Herrera, Hubert Vaudry, Jérôme Leprince, Sylvie Dufour, Karine Rousseau   +10 more
doaj   +1 more source

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Against Cognitive Decline in Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2020
Cognitive impairment is one of the major symptoms in most neurodegenerative disorders such as Alzheimer’s (AD), Parkinson (PD), and Huntington diseases (HD), affecting millions of people worldwide.
Irene Solés-Tarrés, Núria Cabezas-Llobet, David Vaudry, Xavier Xifró   +3 more
doaj   +1 more source

Metabolic reprogramming during neuronal differentiation [PDF]

Cell Death & Differentiation, 2016
Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic neurons undergo neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity.
Agostini M., Romeo F., Inoue S., Niklison-Chirou M. V., Elia A. J., Dinsdale D., Morone N., Knight R. A., Mak T. W., Melino G.   +9 more
openaire   +3 more sources