Results 251 to 260 of about 1,189,995 (318)

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

SARS-CoV-2 infects olfactory neurons and basal stem cells and induces axonal degeneration through TRPV1 activation. [PDF]

iScience
Co VA, Liu S, Tam RC, Mok BW, Lam AH, Chen H, Hong Y.   +6 more
europepmc   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Harnessing the stem cell potential in the human hippocampus to limit cognitive aging. [PDF]

PLoS Biol
Mhatre S, Moore DL.
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

ATF3-based peripheral neural tract tracing. [PDF]

Front Neuroanat
Gautron L.
europepmc   +1 more source

Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders. [PDF]

NPJ Biol Timing Sleep
Boareto M, Mendoza J, Holst SC, Kalsbeek A, Prinssen E, Grundschober C.   +5 more
europepmc   +1 more source

Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats. [PDF]

Front Aging Neurosci
Sugimura T, Saito Y.
europepmc   +1 more source

Thyroid hormones maintain parvalbumin neuron functions in the mouse neocortex. [PDF]

iScience
Ren J, Markossian S, Guyot R, Aubert D, Riet F, Brocard J, Descamps A, Wong J, Li D, Cauli B, Gallopin T, Flamant F, Richard S.   +12 more
europepmc   +1 more source

Expression of Axonal Transport Proteins in Dopaminergic Neurons of the Substantia Nigra in Mouse Models of Preclinical and Clinical Stages of Parkinson's Disease. [PDF]

Int J Mol Sci
Kolacheva A, Troshev D, Antonova A, Pavlova E, Bogdanov V, Kalashnikova V, Popova A, Shchepina M, Ugrumov M.   +8 more
europepmc   +1 more source