Results 31 to 40 of about 180,995 (352)

Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline

Case Reports in Medicine, 2012
Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. We
David J. Kopsky, Remko Liebregts, Jan M. Keppel Hesselink   +2 more
doaj   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Neuropathic pain in leprosy [PDF]

Leprosy Review, 2004
Chronic neuropathic pain in treated leprosy has received scant attention. In this article the concept, clinical features and diagnosis of neuropathic pain are reviewed. The possible pathophysiological mechanisms, treatment challenges and research needs in this area are discussed.
Maija Haanpää, Aki Hietaharju, Diana N. J. Lockwood   +2 more
openaire   +3 more sources

A modified score to identify and discriminate neuropathic pain: a study on the German version of the neuropathic pain symptom inventory (NPSI)

BMC Neurology, 2011
Background Neuropathic pain must be correctly diagnosed for optimal treatment. The questionnaire named Neuropathic Pain Symptom Inventory (NPSI) was developed in its original French version to evaluate the different symptoms of neuropathic pain.
Lungenhausen Margitta, Frettlöh Jule, Rogausch Jan P, Richter Helmut, Sommer Claudia, Maier Christoph   +5 more
doaj   +1 more source

Oral ketamine vs placebo in patients with cancer-related neuropathic pain [PDF]

, 2018
Ketamine hydrochloride is used as an adjuvant treatment for cancer-related neuropathic pain, but evidence of its effectiveness is limited.1 Findings of a large trial investigating the use of ketamine for general cancer pain were negative, but the ...
Fallon, Marie T., Kelly, Caroline A., Laird, Barry J. A., Lewsley, Liz-Anne, Norrie, John, Paul, James, Wilcock, Andrew   +6 more
core   +4 more sources

Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study. [PDF]

PLoS ONE, 2018
The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal research has suggested that lysophosphatidic acids, which are bioactive lipids produced by autotaxin from lysophosphatidylcholine, may play key roles in the initiation ...
Ken Kuwajima, Masahiko Sumitani, Makoto Kurano, Kuniyuki Kano, Masako Nishikawa, Baasanjav Uranbileg, Rikuhei Tsuchida, Toru Ogata, Junken Aoki, Yutaka Yatomi, Yoshitsugu Yamada   +10 more
doaj   +1 more source

Managing the symptoms of neuropathic pain: An exploration of patients' experiences [PDF]

, 2007
The debilitating effects of chronic neuropathic pain on everyday life are considerable but little is known about how individual sufferers manage these effects.
Bennett, Calnan, Challapalli, Gilron, Henwood, Hollingshead, Innes Reid, Kitzinger, MacDougall, Mailis-Gagnon, McCracken, McDermott, Meyer-Rosberg, Michelle Briggs, Mike I. Bennett, NCCAM. National Center for Complementary and Alternative Medicine, National Institutes for Health, Nicholas, Norrbrink Budh, Pope, Rapson, Risdon, S. José Closs, Saarto, Vicki Staples, Vlaeyen, Wardell   +25 more
core   +1 more source

Somatosensory profiles but not numbers of somatosensory abnormalities of neuropathic pain patients correspond with neuropathic pain grading. [PDF]

PLoS ONE, 2012
Due to the lack of a specific diagnostic tool for neuropathic pain, a grading system to categorize pain as 'definite', 'probable', 'possible' and 'unlikely' neuropathic was proposed.
Karl-Heinz Konopka, Marten Harbers, Andrea Houghton, Rudie Kortekaas, Andre van Vliet, Wia Timmerman, Johan A den Boer, Michel M R F Struys, Marten van Wijhe   +8 more
doaj   +1 more source

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Neuropathic Pain

Current Opinion in Neurology, 2001
Damage to peripheral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed to be responsible for the generation of neuropathic pain. Recent data in animal models show that alterations in the properties of undamaged neurones that project into a damaged nerve can also play an important role.
Alice Goodman
openalex   +3 more sources