Results 21 to 30 of about 206,368 (387)

Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

eLife, 2020
Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour.
Luis Alfonso Yañez-Guerra, Xingxing Zhong, Ismail Moghul, Thomas Butts, Cleidiane G Zampronio, Alexandra M Jones, Olivier Mirabeau, Maurice R Elphick   +7 more
doaj   +1 more source

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Nature Communications, 2021
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity ...
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu   +13 more
doaj   +1 more source

Synthesis of receptor antagonists of neuropeptide Y. [PDF]

Proceedings of the National Academy of Sciences, 1992
We report the synthesis of receptor antagonists of neuropeptide Y (NPY) by a strategy based on synthesis of mixtures of analogs and the subsequent isolation and identification of receptor antagonists from these mixtures. After screening a series of mixtures of NPY analogs by using an NPY antagonist assay, two potent receptor antagonists, designated PYX-
Meikyo Shimizu, Kazuhiko Tatemoto, Michael J. Mann   +2 more
openaire   +3 more sources

NPY1R (neuropeptide Y receptor Y1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NPY1R (neuropeptide Y receptor Y1), with data on DNA, on the protein encoded, and where the gene is implicated.
M. Ruscica, E. Dozio, L. Passafaro, P. Magni   +3 more
openaire   +4 more sources

Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders

Frontiers in Neural Circuits, 2022
Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello, Rodolfo J. Flores, Hector E. Yarur, Huikun Wang, Monique Awanyai, Miguel A. Arenivar, Rosario B. Jaime-Lara, Rosario B. Jaime-Lara, Hector Bravo-Rivera, Hugo A. Tejeda   +9 more
doaj   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Identification of neuropeptides and neuropeptide receptor genes in Phauda flammans (Walker)

Scientific Reports, 2022
Neuropeptides and neuropeptide receptors are crucial regulators to insect physiological processes. The 21.0 Gb bases were obtained from Illumina sequencing of two libraries representing the female and male heads of Phauda flammans (Walker) (Lepidoptera ...
Hai-Pan Wu, Xiao-Yun Wang, Jin Hu, Ran-Ran Su, Wen Lu, Xia-Lin Zheng   +5 more
doaj   +1 more source

Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest [PDF]

, 2018
Hylobius abietis (Linnaeus), or large pine weevil (Coleoptera, Curculionidae), is a pest of European coniferous forests. In order to gain understanding of the functional physiology of this species, we have assembled a de novo transcriptome of H. abietis,
Davies, Shireen-Anne, Dow, Julian A.T., Inward, Daegan J.G., Marley, Richard, Pandit, Aniruddha A., Predel, Reinhard, Ragionieri, Lapo, Yeoh, Joseph G.C.   +7 more
core   +1 more source

Y₁ and Y₂ receptors for neuropeptide Y [PDF]

FEBS Letters, 1989
By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Thue W. Schwartz, Rolf Håkanson, Søren P. Sheikh   +2 more
openaire   +3 more sources

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source