Results 61 to 70 of about 206,368 (387)
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study reveals a complex peptidomic landscape in the mouse somatosensory cortex, identifying locally released and potentially transported neuropeptides using a membrane‐free nanodialysis sampling probe coupled with nanoLC‐timsTOF mass spectrometry.
Keyin Li +6 more
wiley +2 more sources
Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]
, 2013 Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core +1 more source
Advanced Science, EarlyView.Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui +6 more
wiley +1 more source
PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]
, 2018 The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon +2 more
core +2 more sources
CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]
, 2020 Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor +7 more
core +1 more source
Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
Cloning characterisation and expression of a G-protein-couple receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide PSFHSWSamide as its endogenous ligand [PDF]
, 1997 No description ...
Burke, Julian F +7 more
core +1 more source
DINeR: Database for Insect Neuropeptide Research [PDF]
, 2017 Neuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system.
Davies, Shireen-Anne +5 more
core +1 more source
Cloning and Expression of a Novel Neuropeptide Y Receptor [PDF]
Journal of Biological Chemistry, 1996 The neuropeptide Y family of peptides, which includes neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP), are found in the central and peripheral nervous system and display a wide array of biological activities. These actions are believed to be mediated through pharmacologically distinct G protein-coupled receptors, and, to date ...
David H. Weinberg +12 more
openaire +3 more sources