Results 171 to 180 of about 17,667,571 (207)

Role of neuropilin-2 in skin inflammation and lymphatic function

, 2013
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Neuropilin‐2 expression in cancer

Histopathology, 2012
Jubb A M, Sa S M, Ratti N, Strickland L A, Schmidt M, Callahan C A & Koeppen H 
(2012) Histopathology 61, 340–349Neuropilin‐2 expression in cancerAims:  Neuropilin‐2 is a coreceptor for vascular endothelial growth factor family members. Blockade of neuropilin‐2 is able to suppress lymphogenous metastasis in preclinical models. The aim of this study
Maike Schmidt, Hartmut Koeppen
exaly   +3 more sources

Targeting Neuropilin‐2 in Lymphatic Malformation

The FASEB Journal, 2022
Lymphatic malformations (LM) are sporadic, non‐familial congenital lesions consisting of dilated, abnormal lymphatic vessels that can cause severe lymphedema, disfigurement, organ dysfunction, and in some cases morbidity. These vascular anomalies grow slowly but progress over time and recur after surgery; no effective drugs or ...
Yao Gao, Dakshnapriya Balasubbramanian, Arin Greene, Hong Chen, Diane Bielenberg   +4 more
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Neuropilin-2: a novel biomarker for malignant melanoma? [PDF]

Human Pathology, 2012
Neuropilin-2, a cell surface receptor involved in angiogenesis and axonal guidance, has recently been shown to be a critical mediator of tumor-associated lymphangiogenesis. Given that lymphangiogenesis is a major conduit of metastasis in melanomas and that blocking neuropilin-2 function in vivo is effective in inhibiting tumor cell metastasis, we ...
Mark S Eller, Alaa Naif, Klaus J Busam
exaly   +3 more sources

Role of neuropilin-2 in the immune system

Molecular Immunology, 2017
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2).
S, Schellenburg, A, Schulz, D M, Poitz, M H, Muders   +3 more
exaly   +3 more sources

Schwann cell‐autonomous role of neuropilin‐2

Journal of Neuroscience Research, 2005
AbstractNeuropilins and group A plexins are components of receptor complexes for class 3 semaphorins, gradients of which help to guide migration of neural progenitor cells and axonal growth cones during development. We demonstrated previously that neuropilins and class 3 semaphorins are induced in sciatic nerve by crush or transection.
J, Ara, P, Bannerman, F, Shaheen, D E, Pleasure   +3 more
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Advanced glycation end-products suppress neuropilin-1 expression in podocytes

Kidney International, 2009
Advanced glycation end products (AGEs) have been linked to the pathogenesis of diabetic nephropathy. Here we tested the effect of AGE-modified bovine serum albumin (AGE-BSA) on differentiated mouse podocytes in culture. Differential display and real-time
Tzvetanka Bondeva, Christiane Ruster, Sybille Franke   +2 more
exaly   +2 more sources

Neuropilin 2 and soluble neuropilin 2 in neuroendocrine neoplasms

Endocrine-Related Cancer
Neuropilin 2 (NRP2), a transmembrane non-tyrosine kinase receptor, has been described as a potential critical player in the tumourigenesis of several solid cancers and particularly in neuroendocrine neoplasms (NENs). A soluble form of NRP2 (sNRP2) has been previously described and corresponds to a truncated splice isoform.
Laura Gerard, Céline Patte, Laurence Chardon, Valérie Hervieu, Léa Payen, Marion Allio, Claire Marx, Hugo Clermidy, Alice Durand, Patrick Mehlen, Julien Bollard, Gilles Poncet, Colette Roche, Benjamin Gibert, Thomas Walter   +14 more
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Neuropilin-2 promotes melanoma growth and progression in vivo

Melanoma Research, 2016
Tumor cell interactions with their microenvironment, and neighboring endothelial cells in particular, are critical for tumor cell survival and the metastatic process. Within the spectrum of tumors, melanomas are notorious for their ability to metastasize at a relatively early stage of development; however, little is known about the molecular pathways ...
Whei F, Moriarty, Edward, Kim, Stephanie A, Gerber, Hans, Hammers, Rhoda M, Alani   +4 more
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Neuropilin-2 is overexpressed in the rat brain after limbic seizures

Brain Research, 2002
Structural rearrangement and synaptic reorganization are known to occur in the brain after seizures. If neuronal rearrangement after seizures always results in abnormal hyperexcitability, it would provide an accurate pathway to the appropriate target and as a result, it may be the mechanism of epileptogenesis.
Shuichi, Shimakawa, Shuhei, Suzuki, Ryohei, Miyamoto, Kimitaka, Takitani, Katsuji, Tanaka, Takuya, Tanabe, Eiji, Wakamiya, Fusao, Nakamura, Miyuki, Kuno, Shushi, Matsuura, Yasuyoshi, Watanabe, Hiroshi, Tamai   +11 more
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