Results 181 to 190 of about 17,667,571 (207)

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

Development, 2002
Neuropilin 2 is a receptor for class III semaphorins and for certain members of the vascular endothelial growth factor family. Targeted inactivation of the neuropilin 2 gene (Nrp2) has previously shown its role in neural development. We report that neuropilin 2 expression in the vascular system is restricted to veins and lymphatic vessels.
Li, Yuan, Delphine, Moyon, Luc, Pardanaud, Christiane, Bréant, Marika J, Karkkainen, Kari, Alitalo, Anne, Eichmann   +6 more
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Neuropilin-2 Promotes the Development of Neuroendocrine Prostate Cancer

SSRN Electronic Journal, 2021
Neuroendocrine prostate cancer (NEPC), a lethal subset of the disease, is characterized by loss of AR signaling and resulting resistance to AR-targeted therapy during neuroendocrine transdifferentiation, for which the molecular mechanisms remain unclear.
Jingjing Li, Jing Wang, Lijuan Yin, Tianjie Pu, Tzu-Ping Lin, Allen C. Gao, Jason Wu   +6 more
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Neuropilin-2 contributes to LPS-induced corneal inflammatory lymphangiogenesis

Experimental Eye Research, 2016
Neuropilin-2 (NP2), a high-affinity kinase-deficient co-receptor for vascular endothelial growth factor (VEGF)-C, is involved in embryonic vessel development, tumor growth, tumor lymphangiogenesis and metastasis. However, the pathological role of NP2 in other disorders, particularly under inflammatory lymphangiogenic conditions, remains largely unknown.
Xianling, Tang, Junfeng, Sun, Lingling, Du, Haitao, Du, Liyuan, Wang, Jieying, Mai, Fengmin, Zhang, Ping, Liu   +7 more
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Neuropilin-2 as a Novel Angiogenic Player: deciphering the contributions of neuropilin-2 during developmental and pathological angiogenesis [PDF]

, 2022
Angiogenesis, the growth of neovasculature from pre-existing vessels, is driven by the stimulation of endothelial cells (ECs) by pro-angiogenic factors to invade the surrounding tissue and expand the vascular network. The extracellular matrix (ECM) component fibronectin (FN), and its canonical receptors, α5β1 and αvβ3 integrins are upregulated on ...
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Role of neuropilin‐2 in the ipsilateral growth of midbrain dopaminergic axons

European Journal of Neuroscience, 2013
Abstract Axonal projections in the CNS can be categorized as either crossed or uncrossed. Crossing and uncrossing of axons has been explained by attractive and repulsive molecules like N etrin‐1 and S
Makio, Torigoe, Kenta, Yamauchi, Atsushi, Tamada, Ikuo, Matsuda, Atsu, Aiba, Valérie, Castellani, Fujio, Murakami   +6 more
openaire   +2 more sources

Neuroendocrine Cells along the Digestive Tract Express Neuropilin-2

Biochemical and Biophysical Research Communications, 2001
Neuropilin-2 (np-2) is a receptor for semaphorin-3F (sema-3F) and semaphorin-3C (sema-3C). These semaphorins repel tips of growing axons that express np-2. In addition, np-2 functions as a receptor for heparin binding forms of the angiogenic factor vascular endothelial growth factor (VEGF) such as VEGF145 and VEGF165.
T, Cohen, Z, Gluzman-Poltorak, A, Brodzky, V, Meytal, E, Sabo, I, Misselevich, M, Hassoun, J H, Boss, M, Resnick, D, Shneyvas, S, Eldar, G, Neufeld   +11 more
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Neuropilin 2 in Osteoblasten

Neuropilin-2 (Nrp2) wird zunehmend als potenzielles therapeutisches Ziel bei Knochenmetastasen des kastrationsresistenten Prostatakarzinoms (CRPC) diskutiert. Es spielt eine Rolle in der Regulation der Osteogenese, doch seine spezifische Funktion in Osteoblasten ist bislang unzureichend verstanden.
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Neuropilin 2 protects human from Chikungunya virus

2021
Chikungunya virus (CHIKV) is one of the most common mosquito borne diseases in Malaysia. It is transmitted to human via Aedes mosquito. Once the virus enter the human body, the virus will hijack the human system and replicate inside human. This will cause human having fever, headache and most commonly joint pain.
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Neuropilin 2 Deficiency Prolongs Skin Inflammation and Edema

The FASEB Journal, 2016
The vasculature is involved in the progression and resolution of inflammation. Blood and lymphatic capillaries express vascular endothelial growth factor (VEGF) receptors that regulate fluid flow into and out of the interstitium. Neuropilin 2 (Nrp2), a unique receptor that binds VEGF‐A, VEGF‐C/D or semaphorin 3F (SEMA3F) ligands ...
Diane Renee Bielenberg, Patrick Mucka, Nicholas Levonyak, Elena Geretti, Bernadette M.M. Zwaans, Xiaoran Li, Irit Adini, Michael Klagsbrun, Rosalyn M Adam   +8 more
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Neuropilin-2 gene expression correlates with malignant progression in cutaneous melanoma

British Journal of Dermatology, 2014
It is currently not possible to predict the metastatic potential of early-stage melanoma lesions by histological examination alone; however, a significant number of thin melanomas will progress over time to advanced disease. Molecular biomarkers that could identify patients with melanoma at high risk at the time of original diagnosis would contribute ...
M, Rossi, J, Tuck, O-J, Kim, I, Panova, J T, Symanowski, M, Mahalingam, A I, Riker, R M, Alani, B, Ryu   +8 more
openaire   +2 more sources