Results 91 to 100 of about 2,294 (205)

Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation

Molecular Cancer, 2010
Background Neuropilin is a transmembrane receptor for vascular endothelial growth factor (VEGF) and is expressed in normal endothelial cells and upregulated in cancer cells.
Staton Carolyn A, Chirakkal Haridasan, Waby Jennifer S, Yu Danny CW, Corfe Bernard M   +4 more
doaj   +1 more source

Bad vessels beware! Semaphorins will sort you out!

EMBO Molecular Medicine, 2015
Secreted class 3 semaphorins (Sema3), which signal through plexin receptors and mostly use neuropilins (Nrps) as co‐receptors, were initially identified for their ability to steer navigating axons in the developing embryo.
Guido Serini, Luca Tamagnone
doaj   +1 more source

The role of the neuropilins in tumour angiogenesis and tumour progression [PDF]

, 2017
Neuropilins (NRPs) are multifunctional receptors for class 3 semaphorins, which are responsible for axon guidance during the development of the nervous system in vertebrates, and for vascular endothelial growth factors (VEGFs), essential for vascular ...
Liu, D, Frankel, P, Zachary, I, Milagre, C, Mahmoud, M   +4 more
core  

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone (GnRH) System

Frontiers in Endocrinology, 2013
The semaphorin proteins are among the best-studied families of guidance cues, contributing to morphogenesis and homeostasis in a wide range of tissue types.
Andrea eMessina, Paolo eGiacobini
doaj   +1 more source

Prognostic value and in vitro biological relevance of Neuropilin 1 and Neuropilin 2 in osteosarcoma

American journal of translational research, 2015
Neoadjuvant chemotherapy in osteosarcoma increased the long-term survival of patients with localized disease considerably but metastasizing osteosarcoma remained largely treatment resistant. Neuropilins, transmembrane glycoproteins, are important receptors for VEGF dependent hyper-vascularization in tumor angiogenesis and their aberrant expression ...
Boro, Aleksandar, Arlt, Matthias Je, Lengnick, Harald, Robl, Bernhard, Husmann, Maren, Bertz, Josefine, Born, Walter, Fuchs, Bruno   +7 more
openaire   +3 more sources

Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro

Brazilian Journal of Medical and Biological Research, 2018
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling ...
I. Valiulyte, V. Preitakaite, A. Tamasauskas, A. Kazlauskas   +3 more
doaj   +1 more source

The Nervous System Development Regulator Neuropilin-1 as a Potential Prognostic Marker and Therapeutic Target in Brain Cancer. [PDF]

Cancers (Basel), 2023
Rodrigues EM, Giovanini AF, Ribas CAPM, Malafaia O, Roesler R, Isolan GR.   +5 more
europepmc   +1 more source

Semaphorin 3A, A Potential Target for Low Back Pain.

Frontiers in Aging Neuroscience, 2015
Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found ...
Pengbin eYin, Houchen eLv, Lihai eZhang, Licheng eZhang, Peifu eTang   +4 more
doaj   +1 more source

Molecular and Cellular Mechanisms of Angiogenesis The role of neuropilins in cell signalling

, 2020
NRPs (neuropilins) are receptors for class 3 semaphorins, polypeptides essential for axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines.
Paul Frankel, Ian C Zachary, Ian M Evans, Caroline Pellet-Many   +3 more
core  

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

Neoplasia: An International Journal for Oncology Research
Metastasis is the main cause of death from solid tumors. Therefore, identifying the mechanisms that govern metastatic growth poses a major biomedical challenge.
L Recalde-Percaz, I de la Guia-Lopez, P Linzoain-Agos, A Noguera-Castells, M Rodrigo-Faus, P Jauregui, A Lopez-Plana, P Fernández-Nogueira, M Iniesta-González, M Cueto-Remacha, S Manzano, R Alonso, N Moragas, C Baquero, N Palao, E Dalla, FX Avilés-Jurado, I Vilaseca, X León-Vintró, M Camacho, G Fuster, J Alcaraz, J Aguirre-Ghiso, P Gascón, A Porras, A Gutiérrez-Uzquiza, N Carbó, P Bragado   +27 more
doaj   +1 more source